| 海滩牵牛有效部位对巴豆油所致小鼠耳肿胀抑制作用的研究 |
| |
| 引用本文： | 陈一村,蔡聪艺,冀宾,高分飞,张艳美,王锦芝,黄展勤,石刚刚.海滩牵牛有效部位对巴豆油所致小鼠耳肿胀抑制作用的研究[J].汕头大学医学院学报,2010,23(1):7-9,F0002. |
| |
| 作者姓名： | 陈一村 蔡聪艺 冀宾 高分飞 张艳美 王锦芝 黄展勤 石刚刚 |
| |
| 作者单位： | 汕头大学医学院药理学教研室,广东,汕头,515041 |
| |
| 基金项目： | 广东省科技计划资助项目，广东省中医药局资助项目，国家自然科学基金资助项目，广东省自然科学基金团队资助项目 |
| |
| 摘 要： | 目的：研究中草药海滩牵牛有效部位（EFIS）对巴豆油引起小鼠耳肿胀抑制作用。方法：制作巴豆油所致小鼠耳肿胀模型，观察EFIS对巴豆油引起小鼠耳肿胀的抑制作用；同时研究EFIS对耳肿胀组织炎症细胞渗出和NO浓度、髓过氧化物酶（MPO）活性的影响。结果：与模型组比，EFLS（150、300、600mg／kg）能明显减轻巴豆油引起小鼠耳肿胀（P〈0．05）；能不同程度减少耳肿胀组织炎症细胞渗出；能明显降低耳肿胀组织NO浓度与MPO活性（P〈0．05）。结论：EFIS具有较强的抗炎活性，其作用与抑制炎症过程中的渗出和水肿、血管通透性的改变、炎症介质的产生有关。
|
| 关 键 词： | 海滩牵牛 巴豆油 抗炎 耳肿胀 髓过氧化物酶 一氧化氮 |
Inhibitory Effect of the Effective Fraction of Ipomoea Stolonifera on Croton Oil-induced Mouse Ear Edema |
| |
| CHEN Yi-cun,CAI Cong-yi,JI Bin,GAO Fen-fei,ZHANG Yan-mei,WANG Jin-zhi,HUANG Zhan-qin,SHI Gang-gang.Inhibitory Effect of the Effective Fraction of Ipomoea Stolonifera on Croton Oil-induced Mouse Ear Edema[J].Journal of Shantou University Medical College,2010,23(1):7-9,F0002. |
| |
| Authors: | CHEN Yi-cun CAI Cong-yi JI Bin GAO Fen-fei ZHANG Yan-mei WANG Jin-zhi HUANG Zhan-qin SHI Gang-gang |
| |
| Institution: | CHEN Yi-cun,CAI Cong-yi,JI Bin,GAO Fen-fei,ZHANG Yan-mei,WANG Jin-zhi,HUANG Zhan-qin,SHI Gang-gang(Department of Pharmacology,Shantou University Medical College,Shantou 515041,China) |
| |
| Abstract: | Objective:To investigate the inhibitory effect of the effective fraction(EFIS)of ipomoea stolonifera on croton oil-induced mouse ear edema.Methods:The anti-inflammatory effect from EFIS was evaluated with croton oil-induce ear edema in mice.The levels of NO and myeloperoxidase activity were also studied.Results:EFIS produced significant inhibitions on croton oil-induce ear edema in mice in a dose-dependent manner(P<0.05).EFIS inhibited inflammatory cells accumulation.EFIS reduced the levels of NO and MPO ac... |
| |
| Keywords: | ipomoea stolonifera croton oil anti-inflammation ear edema myeloperoxidase nitric oxide |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
