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山核桃树枝水煎剂对S180荷瘤小鼠抗肿瘤作用的免疫机制研究
引用本文:于晓红,胡艳文,于洋,赵春卉. 山核桃树枝水煎剂对S180荷瘤小鼠抗肿瘤作用的免疫机制研究[J]. 天津中医药, 2006, 23(5): 396-397
作者姓名:于晓红  胡艳文  于洋  赵春卉
作者单位:黑龙江中医药大学,哈尔滨,150040
基金项目:哈尔滨市科技攻关计划资助项目(0114211135-8)
摘    要:[目的]探讨山核桃树枝水煎剂对荷瘤小鼠免疫功能的调节作用及其抗肿瘤机制。[方法]采用S180肉瘤小鼠模型作为研究对象,观察其对荷瘤小鼠外周血白细胞介素-2(IL-2)和白细胞介素-4(IL-4)水平的影响及对CD4 T细胞和CD8 T细胞的调节作用。[结果]山核桃树枝水煎剂可以提高外周血IL-2水平、降低IL-4水平,可以使CD4 T细胞表达增加,CD8 T细胞表达降低。[结论]山核桃树枝水煎剂通过调节荷瘤机体异常的免疫状态而发挥抗肿瘤作用。

关 键 词:山核桃树枝水煎剂  S180肉瘤  肿瘤细胞  T3淋巴细胞亚群
文章编号:1672-1519(2006)05-0420-03
收稿时间:2006-07-11
修稿时间:2006-07-11

Effect of Decoction of Branch of Juglans Maxim on Subpopulation of T-lymphocyte in Peripheral Blood of Tumor-loaded Mice
YU Xiao-hong,HU Yan-wen,YU Yang. Effect of Decoction of Branch of Juglans Maxim on Subpopulation of T-lymphocyte in Peripheral Blood of Tumor-loaded Mice[J]. Tianjin Journal of Traditional Chin Medicine, 2006, 23(5): 396-397
Authors:YU Xiao-hong  HU Yan-wen  YU Yang
Affiliation:Heilongjiang University of TCM, Harbin 150040, China
Abstract:[Objective] To study the regulative effects of decoction of the Branch of Juglans Maxim(DJM) on immunity and the possible mechanism of anti-tumor in tumor-loaded mice with S180 tumor cells. [Methods] The influence of DJM on IL-2, IL-4 and the regulative action of DJM on the CD4 T cells and CD8 T cells in mice bearing S180 tumor cells were observed. [Results] The level of IL-2 increased(P<0.05) by DJM, but the level of IL-4(P<0.05)decreased. The expression of the CD4 T cells increased(P<0.05) and the expression of the CD8 T cells decreased(P<0.05). [Conclusions] The anti-tumor mechanism of DJM may contribute to the regulative effect on abnormal immunological condition in tumor-loaded mice with S180 tumor cells.
Keywords:The decoction of Juglans Maxim's branch (DJM)  S180 sarcoma  Th1/Th2  IL-2  IL-4
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