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| Preparation of Arsenic Trioxide Albumin Microspheres and its Release Characteristics in Vitro | |
| 引用本文： | 周洁,曾甫清,高翔,谢蜀生,魏树礼. Preparation of Arsenic Trioxide Albumin Microspheres and its Release Characteristics in Vitro[J]. 华中科技大学学报(医学英德文版), 2005, 25(3): 310-312,319 |
| 作者姓名： | 周洁 曾甫清 高翔 谢蜀生 魏树礼 |
| 作者单位： | Department of Urology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Department of Urology，Union Hospital，Tongji Medical College，Huazhong University of Science and Technology，Laboratory of Immunopharmacology，Health Science Center，Peking University，Laboratory of Immunopharmacology，Health Science Center，Peking University，Faculty of Pharmacy，Health Science Center，Peking University Wuhan 430022，China，Wuhan 430022，China，Beijing 100083，China，Beijing 100083，China，Beijing 100083，China |
| 基金项目： | This project was supported by State Youth Natural Sci-ences Foundation (No .30200284) . |
| 摘 要： | Arsenic Trioxide (As2O3) has been used as atherapeutic agent and poison for more than 2400years .Because of its toxic and side effects ,it wasnot widely used in clinic for a long period. Re-cently ,it was confirmed that arsenic trioxide caninduce cytotoxicity and apoptosis in many cancercell lines . To reduce its toxic and raise its thera-peutic efficacy , we studied the preparation of arse-nic trioxide albumin microspheres ( As2O3-BSA-NS) and verify its release characteristicsin vitro.Ort… |
| 关 键 词： | 三氧化砷 白蛋白微球体 化学制品 用药方法 |
Preparation of Arsenic Trioxide Albumin Microspheres and its Release Characteristics in Vitro |
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| ZHOU Jie,ZENG Fuqing,GAO Xiang,Xie Shusheng,WEI Shuli. Preparation of Arsenic Trioxide Albumin Microspheres and its Release Characteristics in Vitro[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 2005, 25(3): 310-312,319 | |
| Authors: | ZHOU Jie ZENG Fuqing GAO Xiang Xie Shusheng WEI Shuli |
| Affiliation: | 1. Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China 2. Laboratory of Immunopharmacology, Health Science Center, Peking University, Beijing 100083, China 3. Faculty of Pharmacy, Health Science Center, Peking University, Beijing 100083, China |
| Abstract: | Arsenic trioxide albumin microspheres (As2O3-BSA-NS) were prepared by using methods of chemical cross-linking. The desirability function (DF), calculated according to the size (<1 microm) distribution, drug loading and drug trapping efficiency, was introduced as a total index for the microspheres formulation. Four factors, inculding W/O ratio, decentralization speed, BSA concentration and stirring stabilization time, were selected and arranged in an orthogonal experimental table. The release characteristic was studied by the drug release experiment in vitro. The four factors affected DF differently. Decentralization speed behaved as the maximum (P<0.01), followed by BSA concentration (P<0.05) and the W/O ratio dose (P<0.05). Stirring stabilization time did not influence DF (P>0.05). The release experiment in vitro showed that As2O3 in As2O3-BSA-NS was released more slower than pure As2O3. It was concluded that regular As2O3-BSA-NS may be prepared by the methods of chemical cross-linking, which was optimized by orthogonal experimental analysis of different factors, and the microspheres can release As2O3 slowly. |
| Keywords: | Arsenic trioxide Albumin microspheres chemical cross-linking slow release |
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