创伤后应激障碍患者视觉和听觉诱发电位研究

目的：探讨军人创伤后应激障碍(PTSD)患者视觉诱发电位(VEP)和听觉诱发电位(AEP)的变异及其临床应用价值。方法：应用脑诱发电位仪、症状自评量表(SCL-90)和事件影响量表(IES)对58例军人PTSD患者(患者组)和52名健康军人(对照组)进行VEP和AEP检测以及SCL-90和IES评定，并于治疗3．5个月时进行临床随访。结果：患者组治疗前与对照组比较，VEP的Cz脑区P2和Pz脑区P3波幅显著降低，AEP的Cz脑区P2波幅降低、P3波幅显著增高，Pz脑区P2潜伏期显著延迟；SCL-90总分与IES总分及其大部分因子分显著升高。患者组治疗后，VEP和AEP的变异指标以及SCL-90与IES总分及其各因子分均恢复至正常值范围内；治疗前后VEP和AEP指标变异的差值分别与部分精神症状的减分率呈显著性相关。结论：PTSD患者诱发电位变异特点与精神症状改善相关，有一定的临床应用价值。

Study of visual evoked potential and auditory evoked potential in patients with post-traumatic stress disorder

Objective:To investigate the status and clinical application of visual evoked potential (VEP) and auditory evoked potential (AEP)in patients with post-traumatic stress disorder (PTSD). Method:There were 58 patients with PTSD and 52 normal controls entered into this study,VEP,AEP,symptom check list-90 (SCL-90) and impact of event scaled (IES) were recorded in every subject.The patients with PTSD were followed up with the same markers after 3 5 months treatment. Results:Compared with the control group,the patients with PTSD showed decreased amplitudes (P 2/VEP from Cz,P 3/VEP from Pz,P 2/AEP from Cz),increased amplitude (P 3/AEP from Cz) and longer latency (P 2/AEP from Pz),and higher scores of SCL-90 and IES.The variation of VEP,AEP,SCL-90 and IES changed into normal range after treatment.The changes of VEP and AEP were significantly related to the alleviation of mental symptoms after treatment. Conclusion:It is demonstrated that the features of VEP and AEP in patients with PTSD may be correlated with the improvement of mental symptoms, and deserved further studying.