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| 糖尿病性血管病变与血浆氧化低密度脂蛋白及细胞间黏附分子-1水平变化的关系 | |
| 引用本文： | 袁桂芬,刘成玉,王波.糖尿病性血管病变与血浆氧化低密度脂蛋白及细胞间黏附分子-1水平变化的关系[J].齐鲁医学杂志,2000,15(2):79-80. |
| 作者姓名： | 袁桂芬 刘成玉 王波 |
| 作者单位： | 1. 青岛市市北区医院内科,青岛,266012 2. 青岛大学医学院内科诊断学教研室 3. 莱西市第二人民医院内科 |
| 摘 要： | ①目的 探讨糖尿病性血管病变与血浆低密度脂蛋白（ＯＸ－ＬＤＬ）及可溶性细胞间黏附分子－１（ｓＩＣＡＭ－１）水平变化的关系。②方法 采用酶联免疫吸附法（ＥＬＩＳＡ），检测了６０例２型糖尿病（ＮＩＤＤＭ）病人和４８例健康人血浆ＯＸ－ＬＤＬ和ｓＩＣＡＭ－１水平变化。③结果 ＮＩＤＤＭ病人血浆ＯＸ－ＬＤＬ，ｓＩＣＡＭ－１水平明显增高，与对照组比较差异有极显著性（ｔ＝７．０２１，１１．２０３，Ｐ〈０．００１ |
| 关 键 词： | 糖尿病性血管病变 OX－LDL SICAM－1 ELISA |
THE RELATIONSHIP BETWEEN DIABETIC ANGIOPATHY AND CHANGES OF PLASMA OXIDIZED LOW DENSITY LIPOPROTEIN AND SOLUBLE INTERCELLULAR ADHESION MOLECULE-1 |
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| YUAN Guifen,LIU Chengyu,WANG Bo.THE RELATIONSHIP BETWEEN DIABETIC ANGIOPATHY AND CHANGES OF PLASMA OXIDIZED LOW DENSITY LIPOPROTEIN AND SOLUBLE INTERCELLULAR ADHESION MOLECULE-1[J].Medical Journal of Qilu,2000,15(2):79-80. | |
| Authors: | YUAN Guifen LIU Chengyu WANG Bo |
| Abstract: | Objective To explore the relationship between the diabetic angiopathy and the plasma oxidized low density lipoprotein(OX LDL) and soluble intercellular adhesion molecule 1(sICAM 1).\ Methods\ The changes of OX LDL,sICAM 1 level were measured in 60 patients with type 2 diabetes mellitus(NIDDM) and 48 healthy subjects by ELISA technic.\ Results The OX LDL, sICAM 1 levels were significantly higher in NIDDM patients than those in the controls( t=13.000,21.294, P < 0.001 ), and the increase of OX LDL, sICAM 1 was more obvious in patients with angiopathy than those without angiopathy( t= 7.021 , 11.203, P <0.001). In NIDDM patients, the OX LDL was positively correlated with sICAM 1( r=0.774, P < 0.001 ). Conclusion \ Diabetic angiopathy was closely related to the increase of OX LDL and sICAM 1 levels. |
| Keywords: | diabetes mellitus non insulin dependent lipoproteins LDL cell adhesion molecules |
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