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Resolution pattern of jaundice among children presenting with severe malaria in rural South-West Nigeria

Authors:	OA Osonuga A Osonuga AA Osonuga IO Osonuga

Institution:	1.Department of Pharmacology and Physiology, University of Cape Coast, Cape Coast, Ghana;2.Olabisi Onabanjo University, Remo Campus, Nigeria;3.School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana;4.Department of Nursing, University of Cape Coast, Cape Coast, Ghana

Abstract:	Objective To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether. Methods Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities. They were divided into two groups; ‘Q’ and ‘A’, receiving quinine and artemether, respectively. Jaundice was assessed by clinical examination. Results Sixteen out of 32 children recruited (representing 50%) presented with jaundice on the day of recruitment. The mean age was (7.00°C2.56) years. On day 3, four patients in ‘A’ and six patients in ‘Q’ had jaundice. By day 7, no child had jaundice. Conclusion The study has shown that both drugs resolve jaundice although artemether relatively resolves it faster by the third day.

Keywords:	Jaundice Quinine Artemether Severe malaria South-west Nigeria
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