Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Authors:	Gaurav Kaithwas Raju Gautam Sanjay M Jachak Arvind Saklani

Affiliation:	1.Department of Pharmaceutical Sciences, Assam University, Silchar-788 011, Assam, India;2.Department of Natural Products, National Institute of Pharmaceutical Education and Research (NIPER), Sector 67, SAS Nagar, Mohali- 160 062, Punjab, India.;3.Department of Natural Products, 1-Nirlon Complex, Piramal Life Sciences, Goregaon, Mumbai- 400 063

Abstract:	Objective To evaluate the antiarthritic activity of Ajuga bracteosa using albino rats. Methods The antiarthritic activity of 70% ethanolic extract of Ajuga bracteosa (EEAB) was evaluated against turpentine oil- and formaldehyde- induced acute non immunological and complete freund''s adjuvant (CFA)-induced chronic immunological arthritis in albino rats. Results EEAB showed a significant (P<0.05) and dose dependent inhibitory effect against acute and chronic models of arthritis. EEAB exhibited better antiarthritic activity than the standard aspirin. Conclusions EEAB exhibits a significant and promising antiarthritic activity against acute and chronic arthritis and supports the traditional use of Ajuga bracteosa for rheumatism and other inflammatory diseases.

Keywords:	Ajuga bracteosa Adjuvant Formaldehyde Turpentine Cyclooxygenase
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