Anti-oxidative role of quercetin derived from Allium cepa on aldehyde oxidase (OX-LDL) and hepatocytes apoptosis in streptozotocin-induced diabetic rat |
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Authors: | Mina Bakhshaeshi Arash Khaki Fatemeh Fathiazad Amir Afshin Khaki Elham Ghadamkheir |
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Institution: | 1.Member of Medicine Scientific Association, Islamic Azad University, Tabriz Branch, Tabriz, Iran;2.Department of Pathology, Tabriz Branch, Islamic Azad University, Tabriz, Iran;3.Department of Pharmacognosy, Tabriz University of Medical Sciences, Tabriz, Iran;4.Department of Anatomical sciences, Tabriz University of Medical Sciences, Tabriz, Iran;5.Faculty of Medicine, Scientific Society, Tabriz Branch, Islamic Azad University, Tabriz, Iran |
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Abstract: | ObjectiveTo study the role of Quercetin in streptozotocin-induced diabetes in rats.MethodsWistar male rat (n=40) were allocated into three groups, control group (n=10) and Quercetin (QR) group received 15 mg/kg (IP) QR, (n=10), and diabetic group that received 55 mg/kg (IP) streptozotocin (STZ) (n=20) which was subdivided to two groups of 10; STZ group and treatment group. Treatment group received 55 mg/kg (IP) STZ plus 15 mg/kg QR, daily for 4 weeks, respectively; however, the control group just received an equal volume of distilled water daily (IP). Diabetes was induced by a single (IP) injection of streptozotocin (55 mg/kg). Animals were kept in standard condition. Twenty-eight days after inducing diabetic, 5 mL blood were collected for TAC, MDA and Ox-LDL levels and liver tissues of rat in whole groups were removed then prepared for apoptosis analysis by Tunel method.ResultsApoptotic cells significantly decreased in group that has received 15 mg/kg (IP) Quercetin (P<0.05) in comparison to experimental groups (P<0.05).ConclusionsSince in our study 15 mg/kg (IP) Quercetin have significantly Preventive effect on liver cells damages by reducing number of apoptotic cells in Liver, so it seems that using it can be effective for treatment in diabetic rat. |
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Keywords: | Apoptosis Diabetic Quercetin Streptozotocin Liver Rat |
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