高龄二胎新生儿发育情况与其他新生儿早期发育情况对比研究

目的探讨高龄产妇对新生儿发育的影响,为制定有效干预措施提供科学依据。方法3227例分娩产妇,按照产妇年龄不同分为高龄二胎组(523例)、非高龄二胎组(687例)、高龄一胎组(786例)、非高龄一胎组(1231例)。在四组新生儿出生7 d采用新生儿20项行为神经评分法(NBNA)进行评分,3个月时采用0~6岁小儿神经心理发育检查表(儿心量表)进行神经心理发育评估。比较四组新生儿NBNA评分及适应能力、大运动、精细运动、语言和社交行为评分。结果高龄二胎组的NBNA评分为(38.20±1.95)分,非高龄二胎组的NBNA评分为(38.13±1.85)分,高龄一胎组的NBNA评分为(38.34±1.89)分,非高龄一胎组的NBNA评分为(38.40±1.85)分;高龄二胎组的NBNA评分与非高龄二胎组、高龄一胎组及非高龄一胎组比较,差异无统计学意义(P>0.05)。高龄二胎组大运动、精细运动、适应能力、语言、社交行为及总分均明显低于非高龄二胎组、高龄一胎组及非高龄一胎组,差异具有统计学意义(P<0.05)。结论高龄产妇对新生儿的发育有一定的影响,必须要提早干预,避免儿童出现发育偏差。

A comparative study on the early development of second newborns of high-aged pregnant women and other newborns

Objective To discuss the effect of high age of pregnant women on development of newborns,so as to provide scientific basis for making effective intervention measures.Methods A total of 3227 maternal women were divided into senior second-born group(523 cases),the non-senior second-born group(687 cases),the senior primiparous group(786 cases),and the non-senior primiparous group(1231 cases).On the 7 th d after birth,four groups of newborns were scored by the national behavioral neurological assessment(NBNA),neuropsychological development assessment was made on neuropsychological development checklist for children aged 0-6 at 3 months.The NBNA score,adaptability,large motion,fine motion,language and social behavior scores were compared among the four groups.Results The NBNA score was(38.20±1.95)points in senior second-born group,which was(38.13±1.85)points in non-senior second-born group,(38.34±1.89)points in senior primiparous group,and(38.40±1.85)points in non-senior primiparous group.Senior second-born group had no statistically significant difference in NBNA score,compared with non-senior second-born group,senior primiparous group and non-senior primiparous group(P>0.05).The large motion,fine motion,adaptability,language and social behavior score and total score in senior second-born group was obviously lower than nonsenior second-born group,senior primiparous group and non-senior primiparous group,and the difference was statistically significant(P<0.05).Conclusion The high age of pregnant women has a certain impact on the development of newborns,so early intervention is necessary to avoid deviations in children’s development.