子痫前期患者血清hs-CRP和D-二聚体水平与不良妊娠结局的分析

目的：通过比较子痫前期患者与正常孕妇血清中hs-CRP和D-二聚体（D-D）水平差异,探讨其与不良妊娠结局的关系与意义.方法：选择92例子痫前期患者为研究对象,90例正常孕妇为对照组,分析血清hs-CRP、D-D水平和母婴结局的关系.结果：子痫前期患者血清中hs-CRP和D-D水平均高于正常妊娠组,差异有统计学意义（P＜0.01）,且出现的严重并发症及母婴不良妊娠结局发生率亦较正常妊娠组高,随着病情严重而递增;子痫前期患者血清hs-CRP水平与D-D水平呈显著正相关（r=0.418,P＜0.05）.子痫前期重度组中有不良妊娠结局患者的hs-CRP和D-D水平高于无不良妊娠结局者（P＜0.05）.结论：子痫前期患者血清中hs-CRP和D-D水平与炎症性反应正相关,可能通过促进凝血功能与纤溶抑制功能亢进,产生不良妊娠结局.

Correlation analysis of serum hs-CRP and D-D levels in pre-eclampsia patients and their adverse pregnancy outcomes

Objective： To investigate the potential correlation of the discrepancy level with the adverse pregnancy outcomes through the comparison and analysis of the discrepancy levels of serum high sensitivity C-reactive protein （hs-CRP） and D-dimer （D-D） between the pre-eclampsia patients and the normal pregnant women. Methods： 92 patients with pre-eclampsia and 90 normal pregnant women （selected as the control group） were selected in the study. The serum hs-CRP, D-D levels, genesis of pre-eclampsia and matemal-fetal outcomes were analyzed and compared between the subjects in two groups. Results： The serum hs-CRP level and D-D level of the patients with mild preeclampsia were obviously higher than those of the normal control group （P〈0.01）, and the occurrenee rate of severe complications and matemal-fetal adverse outcomes of the pre-eclampsia patients was higher than those of the normal control group. Moreover, the occurrence rate progressively increased with the worsening of the disease. The serum hs-CRP level and D-D level of the patients with mild pre-eclampsia were positively correlated （r=0.418,P〈0.05）. While for the severe preeclampsia patients, the levels of serum hs-CRP and D-D in patients with adverse pregnant outcomes were higher than those without adverse pregnant outcomes （P〈0.05）. Conclusion： The serum hs- CRP level and D-D level all increased in pre-eclampsia. The findings indicate that the pre-eclampsia is associated with inflammatory response, and it can cause hyperfunction of coagulation and fibrinolytic inhibition which may eventually lead to adverse pregnancy outcomes.