| 抑胶素对大鼠脑胶质瘤的抑瘤效应及对神经细胞粘附分子的影响 |
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| 引用本文： | 崔俐,林卫红,姜慧轶,王绍,张淑琴. 抑胶素对大鼠脑胶质瘤的抑瘤效应及对神经细胞粘附分子的影响[J]. 中风与神经疾病杂志, 2005, 22(2): 128-130 |
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| 作者姓名： | 崔俐 林卫红 姜慧轶 王绍 张淑琴 |
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| 作者单位： | 1. 吉林大学第一医院神经科,吉林,长春,130021
2. 吉林大学基础医学院生理教研室,吉林,长春,130021 |
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| 摘 要： | 目的 研究抑胶素对大鼠脑胶质瘤及神经细胞粘附分子的影响。方法 采用脑立体定向术,在Wistar大鼠脑尾状核接种C6细胞,观察大鼠的生存状态,给药7d后观察肿瘤体积变化及抑胶素、顺铂对鼠脑胶质瘤作用的形态学变化,应用免疫组化法检测用抑胶素前后鼠脑胶质瘤神经细胞粘附分子的变化。结果 实验组大鼠有较好的生存状态,抑胶素对C6鼠脑胶质瘤的生长具有明显的抑制作用,经抑胶素治疗后可见肿瘤内神经细胞粘附分子增加。结论 抑胶素是通过抑制胶质细胞瘤生长,提高神经细胞活性,使神经细胞粘附分子增加,从而抑制恶性胶质瘤细胞体外侵袭能力。
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| 关 键 词： | 抑胶素 脑胶质瘤 神经细胞粘附分子 |
| 文章编号： | 1003-2754(2005)02-0128-03 |
| 修稿时间： | 2004-12-05 |
The etfects of antigliomatin on NCAM expression and rat brain glioma |
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| CUI Li,LIN Wei-hong,JIANG Hui-yi,et al.. The etfects of antigliomatin on NCAM expression and rat brain glioma[J]. Journal of Apoplexy and Nervous Diseases, 2005, 22(2): 128-130 |
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| Authors: | CUI Li LIN Wei-hong JIANG Hui-yi et al. |
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| Abstract: | Objective To study the effect of antigliomatin on the growth of rat brain glioma and the expression of neural cell adhesion molecule (NCAM).Methods C6 glioma cells were injected into the caudate nucleus of rats stereotaxically.The growth of rats was observed after injection.7 days after the treatment of antigliomatin and CDDP,the volume and morphological change of rat glioma were observed and the NCAM expression was detected by immunohistochemical methods.Results Compared with the control group,the growth of rats was much better in the treatment group.The tumor volume of rat glioma was decreased and the expression of NVAM was increased in drug-treatment group.Conlusion It suggests that antigliomatin can inhibit the growth of rat brain glioma by inhibiting the glioma cell viability,increasing the neuronal cell viability,and up-regulating the expression of NCAM. |
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| Keywords: | Antigliomatin Brain glioma NCAM |
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