头孢吡肟与头孢他啶治疗细菌性感染分析

目的：比较头孢吡肟与头孢他啶治疗细菌性感染的药物经济学成本－效果。方法：选择129例患者随机分为头孢吡肟组65例，每次2g,bid 治疗尿路感染每次1g bid；头孢他啶组64例，每次2g,tid，治疗尿路感染每次1g,tid，均静脉滴注，疗程平均11d，采用药物经济学成本－效果分析法。结果：头孢吡肟，头孢他啶治疗细菌性感染有效率分别为92．3％，90．6％，痊愈率分别为72．3％，68．8％，4种类型细菌性感染头孢吡肟成本－效果比均低于头孢他啶，结论：头孢吡肟治疗细菌性感染经济效益 于头孢他啶。

Cost-effectiveness Analysis of Cefepime and Ceftazidime in Treatment of Bacterial Infections

Objective: To evaluate the cost effectiveness and safety of cefepime and ceftazidime in treatment of bacterial infections. Methods: 129 patients with bacterial infections were recruited and randomized into cefepime group and ceftazidime group. Dosage regimens were cefepime 2g bid and ceftazidime 2g q8h; while for urinary tract infections, the dosages were that cefepime 1g bid and ceftazidime 1g tid. The pharmaceutical economics strategy was employed to make the cost effectiveness analysis. Results:The cost effectiveness of cefepime was lower than that of ceftazidime (72.3% Vs 68.8% of cure rate and 92.3% Vs 90.6% of efficacy rate) in the treatment of four kinds of bacterial infections. Conclusion:Cefepime is better than ceftazidime in the treatment of bacterial infections in regard to their cost effectiveness.