| 部分脾切除对大鼠移植免疫耐受形成的影响 |
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| 引用本文： | 夏仁品,沈文律,陈葵. 部分脾切除对大鼠移植免疫耐受形成的影响[J]. 汕头大学医学院学报, 2000, 13(2): 31-32 |
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| 作者姓名： | 夏仁品 沈文律 陈葵 |
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| 作者单位： | 1. 汕头大学医学院第附属医院外科,汕头,515041
2. 汕头大学医学院第附属医院外科研究室,汕头,515041 |
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| 基金项目： | 广东省自然科学基金博士启动基金资助! (编号 :994197) |
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| 摘 要： | 观察脾切除对移植免疫耐受形成的影响。方法：采用分光光度测定法检测脾切除后大鼠血清淀粉 素含量，以ＡＰＡＡＰ法检测Ｔ细胞亚群细胞，并动态观察三种脾切除对移植耐受形成的影响。结果：脾切除可减弱机体初级免疫应答，影响Ｔ细胞亚群，保留５０％脾脏可保留部分脾功能；三种不同量脾切除对免疫耐受形成有协同作用，明显延长移植心存活时间，平均达８０天。结论：５０％脾切除以抑制排斥反应不失为一种有效的措施。
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| 关 键 词： | 部分脾切除 移植免疫耐受 大鼠 |
Effects of Partial Splenectomy on the Induced Immune Tolerance of Experimental Rats |
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| Xia Renpin,Shen Wenlu,Chen Kui. Effects of Partial Splenectomy on the Induced Immune Tolerance of Experimental Rats[J]. Journal of Shantou University Medical College, 2000, 13(2): 31-32 |
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| Authors: | Xia Renpin Shen Wenlu Chen Kui |
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| Abstract: | Objective:To explore the influence of splenectomy on the immune tolerance.Method:The level of serum IgM and the subsets of T_cells of experimental rats with mobilized spleen, partial splenectomy(50%,75%)and total splenectomy was measured after operation,respectively.The effect of splenectomy on rat heartgraft survival time was studied.Results:The splenectomy including 75% splenectomy decreased the primary immune reaction,caused the change of subsets of T_cells.It is suggested that 50% splenectomy reforced the tolerance formation,causing the prolongation of heart allograft survival with an average of over 80 days.Conclusion:Fifty percent splenectomy is an effective method for suppressing graft rejection by decreasing immune reaction. |
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| Keywords: | Splenectomy Immune Tolerance Humoral and Cellular Immune Reaction |
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