甲状腺相关性眼病发生机制及其诊疗的研究进展

本文综述了甲状腺相关性眼病的发病机制以及其诊疗的研究进展。甲状腺相关性眼病是由自身免疫紊乱、环境以及遗传等多方面因素共同作用所致，其作用机制较为复杂，可以通过甲状腺功能检查和影像学检查对其进行诊断。目前，对甲状腺相关性眼病的治疗方法主要有使用糖皮质激素治疗、免疫抑制治疗、放射治疗、手术治疗以及中西医结合治疗等。甲状腺相关性眼病是一种内分泌系统较为难控制的疾病，近年来随着对PPARγ途径的研究深入，阻断PPARγ途径可能成为今后治疗研究的重点方向。

Recent progress in the diagnosis, treatment and pathogenesis of thyroid associated ophthalmopathy

This paper reviews the recent progress in the diagnosis, treatment and pathogenesis of thyroid associated ophthalmopathy. The pathogenesis of thyroid associated ophthalmopathy still remains unclear, while it has been estimated that genetic, environmental and autoimmune factors are involved. Thyroid function tests and imaging studies are used to do the diagnosis. Glucocorticoids, immunosuppression, radiation therapy, surgery and combination therapy are major therapies of thyroid associated ophthalmopathy. Thyroid associated ophthalmopathy is hard to control, but recently, new therapies aiming directly at its immune mechanisms may bring new breakthroughs for the treatment of thy- roid associated ophthalmopathy.