超体质量/肥胖及糖尿病患者血清载脂蛋白B与载脂蛋白A1比值的临床意义 |
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引用本文: | 章国东,汪忠彦,黄翯.超体质量/肥胖及糖尿病患者血清载脂蛋白B与载脂蛋白A1比值的临床意义[J].中国现代医生,2013,51(26):54-56,59. |
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作者姓名: | 章国东 汪忠彦 黄翯 |
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作者单位: | 1. 浙江省金华市文荣医院检验科,浙江金华,321000 2. 浙江省乐清市第五人民医院检验科,浙江乐清,325615 3. 浙江大学医学院附属邵逸夫医院心内科,浙江杭州,310058 |
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基金项目: | 国家自然科学基金(81000064) |
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摘 要: | 目的 探讨ApoB/ApoA1比值在超体质量、肥胖及2型糖尿病患者的变化情况并进一步研究其临床意义.方法 收集2012年7月~2013年4月来我院进行健康体检的受检者181例,以研究对象的BMI及糖调节状况为依据对其进行分组,A组n=38 (20/18)],该组患者具有正常的糖调节与体质量;B组n=41 (24/17)],该组研究对象均为2型糖尿病患者并且具有正常的体质量;C组n=54(31/23)],该组患者为超体质量/肥胖且具有正常的糖调节;D组n=48 (26/22)],该组患者为超体质量/肥胖的2型糖尿病.对四组患者FPG、血脂、hs-CRP、胰岛素水平进行检测,各组患者的胰岛素敏感性采用HOMA-IR进行评价.结果 ①B、C、D组与A组比较具有较高的ApoB/ApoAl比值(P<0.05),D组与B、C组比较水平更高(P<0.05).②ApoB/ApoA1的独立相关因素为年龄、BMI、TG、HDL-C、LDL-C、HOMA-IR(P< 0.05).③高ApoB/ApoA1组患者的年龄、BMI、FPG、TG、TC、LDL-C、HS-CRP、HOMA-IR水平与低ApoB/ApoA1组比较均明显较高,高ApoB/ApoA1组患者也具有较高的高血压及代谢综合征的发生率,HDL-C水平明显将低.④高血压及代谢综合征的发生中ApoB/ApoA1为其独立危险因子(P<0.05).结论 在超体质量、肥胖及糖尿病人群中ApoB/ApoA1比值对其风险评估较为适用.
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关 键 词: | 载脂蛋白B 载脂蛋白A 超体质量 肥胖 糖尿病 |
Study on the clinical significance of overweight/obesity and diabetic pa- tients serum apolipoprotein B and apolipoprotein A1 ratio |
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Authors: | ZHANG Guodong WANG Zhongyan HUANG He |
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Institution: | ZHANG Guodon WANG Zhongyan2 HUANG He3 1.Clinical Laboratory, Jinhua Wenrong Hospital in Zhejiang Province, Jinhua 321000 China; 2. Department of Clinical Laboratory,the Fifth People's Hospital of Yueqing City in Zhejiang Province, Yueqing 325615, China; 3.Department of Cardiology, Sir Run Shaw Hospital Affiliated to Medical College of Zhejiang University, Hangzhou 310058, China |
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Abstract: | Objective To investigate the effect of ApoB/ApoAl ratio in overweight, obese and changes in patients with type 2 diabetes mellitus and study its clinical significance. Methods A total of 181 subjects were collected from July 2012 to April 2013 in our hospital for health examination, BMI and sugar research object's regulation grouped accord- ing to group A (n=38, 20/18), the group of patients with normal glucose regulation and body mass, group B (n--41, 24/17) the study group, all patients with type 2 diabetes mellitus and had normal body weight, group C (n=54,31/23) with normal glucose regulation of the patients were overweight/obesity and, group D (n--48, 26/22), the patients were overweight/ obese type 2 diabetes mellitus. FPG, hs-CRP, blood lipids, insulin levels, insulin sensitivity of patients in four groups were evaluated by HOMA-IR. Results (1)The ApoB/ApoA1 ratio in group B, C, D group were higher than group A(P 〈 0.05), The ApoB/ApoA1 ratio in group D were higher than group B ,C (P 〈 0.05 ). (2)The independent factors asso- ciated with ApoB/ApoA1 were BMI, TG, age, HDL-C, LDL-C, HOMA-IR (P 〈 0.05). (3)Age, BMI, FPG, TG, TC, LDL-C, HS-CRP, HOMA-IR levels in high ApoB/ApoA1 group were significantly higher than low ApoB/ApoA1 group, the rate of hypertension and the prevalence of metabolic syndrome in high ApoB/ApoA1 group were higher, HDL-C level was lower. (4)Hypertension and metabolic syndrome occurred in ApoB/ApoA1 was the independent dan- gerous factor (P 〈 0.05). Conclusion ApoB/ApoA1 in overweight, obesity and diabetic population ratio is applied to the risk assessment. |
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Keywords: | Apolipoprotein B Apolipoprotein A Overweight Obesity Diabetes mellitus |
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