高血压性左室肥大患者血浆Apelin水平的变化 |
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引用本文: | 封芬,周斌,谭安雄,周效思,李涛.高血压性左室肥大患者血浆Apelin水平的变化[J].中国现代医生,2013(22):158-160. |
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作者姓名: | 封芬 周斌 谭安雄 周效思 李涛 |
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作者单位: | [1]邵阳医学高等专科学校,湖南邵阳422000 [2]湖南省邵阳市中心医院内分泌科,湖南邵阳422000 |
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基金项目: | 湖南省教育厅科研课题(10C0295) |
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摘 要: | 目的观察高血压性左室肥大患者血桨Apelin含量的变化情况。方法选取原发性高血压患者60例,根据患者症状、体征及超声心动图结果分为高血压病伴左室肥大组(EH-LVH组,29例)及高血压病伴心力衰竭组(EH-CHF组,31例),正常对照组(30例)则选取经体检筛查后身体健康的中老年体检者。应用酶联免疫吸附法(ELISA)测定三组人员血浆Apelin的含量。结果EH-LVH组血浆Apelin含量明显高于EH-CHF组及正常对照组(P 〈 0.01),而EH-CHF组血浆Apelin含量低于正常对照组(P 〈 0.01)。结论Apelin可能在髙血压性左室肥大的病理生理过程中起着重要作用。
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关 键 词: | Apelin 左室肥大 高血压 心力衰竭 |
The changes of plasma apelin level in hypertensive patients with left ventricular hypertrophy |
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Authors: | FENG Fen ZHOU Bin TANA nxiong ZHOU Xiaosi LI Tao |
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Institution: | 1 .Shaoyang Medical College, Shaoyang 422000, China; 2.Department of Endocrinology, Central Hospital of ShaoyangCity in Hunan Province, Shaoyang 422000,China |
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Abstract: | Objective To observe the changes' of plasma apelin level in patients with hypertensive left ventricular hypertrophy. Methods A total of 60 essential hypertensive patients and 30 elderly healthy controls were selected. Basedon symptoms, signs and echocardiographic findings, 60 essential hypertensive patients were divided into two groups :the essential hypertension with left ventricular hypertrophy group (EH-LVH group, 29 patients), the essential hypertension with heart failure group (EH-CHF group, 31 patients). The levels of plasma apelin of three groups were determined by enzyme linked immunosorbent assay (ELISA). Results The level of plasma apelin was higher in EH-LVHgroup compared with the EH-CHF group and control group (P 〈 0.01), and it was lower in EH-CHF group comparedwith the control group (P 〈 0.01). Conclusion The results indicate that apelin may play an important role in the pathophysiological procedure of hypertensive left ventricular hypertrophy. |
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Keywords: | Apelin Left ventricular hypertrophy Essential hypertension Heart failure |
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