环孢素A联合康力龙治疗慢性再生障碍性贫血疗效研究

目的 探讨环孢素A联合康力龙治疗慢性再生障碍性贫血的疗效.方法 选择2008年12月～2012年12月我院收治确诊的47例慢性再生障碍性贫血患者,根据治疗方法不同分为研究组25例,予以环孢素A联合康力龙治疗,对照组22例,予以康力龙治疗.两组予输血、浓缩血小板及止血、护肝、抗感染等治疗.每月复查血常规2～4次,每3～4个月复查骨髓象1次.比较两组的疗效及不良反应发生情况.结果 研究组总有效率达72.00％,对照组总有效率达54.55％.两组患者治疗后疗效比较有显著性差异(P＜0.05);观察组出现手颤1例,牙龈增生2例,高血压2例,皮肤感觉异常1例,对照组出现肝功能损害2例,经对症处理后缓解,无其他严重不良反应发生.结论 环孢素A联合康力龙治疗慢性再生障碍性贫血是有效的,值得临床推广和应用.

The urative effect of cyclosporin A combined stanozolol on chronic aplas- tic anemia

Objective To explore the effect of cyclosporine A combined with stanozolol in treatment of chronic aplastic anemia. Methods From December 2008 to December 2012 in our hospital, 47 cases of chronic aplastic anemia pa tients, according to the different treatment methods were divided into study group 25 cases, with cyclosporine A and stanozolol treatment, the control group 22 cases treated with stanozolol. The two groups were given the amount of blood transfusion, according to the condition of platelet concentrates and hemostatic, liver protection, anti infection and symptomatic and supportive treatment. The course of treatment was 6 months. Monthly review the blood 2 to 4 times, every 3 to 4 months in the bone marrow of one time. The efficacy and adverse reaction were compared between the two groups. Results The total effective rate in the study group was 72.00%,the total effective rate in the control group was 54.55%. Patients in the two groups after treatment efficacy had significant difference （P〈0.05）, the observation group occurred in 1 cases of hand tremor, 2 cases of gingival hyperplasia, 2 cases of hypertension, abnormal skin feeling 1 case, there were 2 cases of liver function damage, cured after symptomatic treatment, no other serious adverse reac tions. Conclusion The effect of cyclosporin A combined with stanozolol in treatment of chronic aplastic anemia is ef fective, worthy of clinical popularization and application.