急性脑梗死患者同型半胱氨酸、超敏C反应蛋白检测的临床意义

目的探讨急性脑梗死患者同型半胱氨酸（Hey）、超敏C反应蛋白（hs—CRP）检测的临床意义。方法选择我院2011年1月～2012年1月我院确诊的急性脑梗死患者32例，同时选择30例健康体检者作为健康对照组，检测同型半胱氨酸（Hcv）、超敏C反应蛋白（hs—CRP）的变化情况，以及治疗2周后脑梗死组Hey、hs—CRP的变化情况。结果32例急性脑梗死患者的Hey为（16．43±3．88）μmol／L，hs—CRP为（4．28±0．27）mg／L，130名健康对照组患者的Hey为（7．32±1．21）μmol／L，hs—CRP为（1．12±0．34）mg／L，病例组的Hey、Hs—CRP含量均明显高于健康对照组，两组分别比较差异有统计学意义（P〈0．05）；病例组入院时Hcy为（17．34_＋3．89）umol／L，hs—CRP为（3．61±0．35）mg／L，治疗2周后，病例组Hcy为（11．96±4．02）μmol／L，hs—CRP为（1．24±0．52）mg／L，上述治疗前后分别比较差异有统计学意义（P〈0．05）。结论同型半胱氨酸及超敏C反应蛋白的检测对于急性脑梗死的诊断、治疗及病情监测与预后具有重要的临床诊断价值。

The clinical significance of homocysteine, high-sensitivity C-reactive protein in patients with acute cerebral infarction

Objective To investigate clinical significance of detection homocysteine （Hcy）, high-sensitivity C-reactive protein （hs-CRP） of patients with acute cerebral infarction. Methods Serected 32 cases diagnosed patie~Lts with acute cerebral infarction in our hospital from January 2011 to January 2012, 30 healthy subjects as control group, deteced the Hcy,hs-CRP changes, and cerebral infarction group Hcy, hs-CRP changes after two weeks of treatment. Results The 32 patients with acute cerebral infarction Hcy was （16.43±3.88）μmol/L, hs-CRP was （428±43.27） mg/L mad 30 healthy control patients Hcy was （7.32±1.21） μmol/L, Hs-CRP was （1.12±0.34） rag/L, acute cerebral infarction cases of Hcy, hs-CRP content was significantly higher than the healthy control group, the two groups were compared, the difference of Hcy, hs-CRP was statistically significant betwecen two groups （P 〈 0.05）; case group admission Hcy （17.34±3.89）μmol/L, hs-CRP was （3.61＋0.35） mg/L, after two weeks of treatment the case group Hcy （11.96±4.02） μmol/L, hs-CRP （1.24±0.52）mg/L, the treatment before and after treatment were compared, after treatment 2 weeks, the patient group of Hcy, Hs-CRP content was significantly lower than the time of admission, the difference was statistically significant （P 〈 0.05）. Conclusion Homocysteine and high-sensitivity C-reactive protein detection, treatment and monitoring of the disease and the prognosis for the diagnosis of acute cerebral infarction has important clinical diagnostic value.