右美托咪定用于腰硬联合麻醉下妇科腹腔镜手术的临床研究

目的观察右美托咪定用于CESA下妇科腹腔镜手术的安全性和可行性。方法选择90例择期于CESA下行腹腔镜手术的妇科患者，随机分为右美托咪定组（A组）、丙泊酚组（B组）和安慰剂组（C组）。记录静脉用药前（T1），静脉用药后10min（T2）、30min（T3）、60min（T4），术毕（T5）的HR、MAP、SpO2、pETC02、RR、BIS。结果三组患者T2、T3、T4、T5时均出现不同程度的HR、BIS、OAA／S评分下降；但与C组相比较，A组较B组下降更明显．差异有统计学意义（P〈0．05）；B组较A组MAP、pETC02、RR显著降低，差异有统计学意义（P〈0．05）。结论右美托咪定用于CESA下妇科腹腔镜手术麻醉效果好．操作简单，安全可行。

Clinical observation of dexmedetomidine for CESA in the gynecologic la- paroscopic operation

Objective To observe safety and feasibility of dexmedetomidine for CESA in gynecologic laparoscopic op- eration. Methods A total of 90 cases of CESA underwent laparoscopic operation in gynecologic patients were randomly divided into dexmedetomidine group （group A）, propofol group （B group） and placebo group （group C）. HR, MAP, SpO2, pETCO2, RR, BIS were recoreded before the time of intravenous infusion of sedative drugs before （T1）, intravenous seda- tion drugs after 10 min （T2）, 30 min （T3）, 60 rain （T4）, and the end of operation （Ts）. Results Three groups of patients T2, T3, T4 showed varying degrees of HR, BIS, OAA/S score decreased; Compared with groups C and A,group B de- creased more significantly, the difference was statistically significant （P 〈 0.05）; MAP, pETCO2 RR charged larger in group B than that in group A, and the difference was statistically significant （P 〈 0.05）. Conclusion Dexmedetomidine given for CESA gynecologic laparoscopic operation has good anesthetic effect, and is simple, safe and feasible.