奈达铂+5-Fu联合调强适形放疗治疗中晚期宫颈癌的临床观察

目的 观察奈达铂+5-Fu联合调强适形放疗治疗中晚期宫颈癌的疗效与安全性.方法 选择我院2006年3月～2008年3月46例经病理确诊的中晚期宫颈癌患者,在调强适形放疗基础上结合奈达铂+5-Fu联合化疗,本组患者为观察组,同时选择同期调强适形放疗的46例中晚期宫颈癌患者作为对照组,对患者近期疗效、不良反应进行观察,所有患者均随访6～60个月,比较远期疗效.结果 观察组总有效率89.13％;对照组总有效率63.04％;观察组近期疗效明显好于对照组,观察组1年、3年、5年生存率分别是100.0％、80.43％、65.22％;3年、5年生存率明显大于对照组,差异具有显著性(P＜0.05).两组毒副反应发生率差异无显著性(P＞0.05).结论 奈达铂+5-Fu联合调强适形放疗治疗中晚期宫颈癌无论是近期效果还是远期疗效,均好于单纯放疗,而且毒副反应未见高于对照组,具有较高的安全性.

Clinical observation on nedaplatin and 5-Fu combined with intensity modulated conformal radiotherapy in the treatment of middle and ad- vanced cervical cancer

Objective To observe the clinical effect and security of nedaplatin and 5-Fu combined with intensity modulated conformal radiotherapy in the treatment of middle and advanced cervical cancer. Methods A total of 46 cases with middle and advanced cervical cancer from our hospital in March, 2006-March, 2008 were observation group,they were given nedaplatin and 5-Fu combined with Intensity modulated conformal radiotherapy, 46 patients with middle and advanced cervical cancer in the same period of intensity modulated conformal radiotherapy were control group. Observed the short-term curative effect and adverse reaction. All patients were followed up for 6 to 60 months, compared the long-term curative effect of two groups. Results The total effective rate of observation group was 89.13%; the total effective rate of control group was 63.04%; the short-term curative effect of observation group was better than control group,1-year,3-year,5-year survival rate of observation group were 100.0% ,80.43% ,65.22% ;3- year and 5-year survival rate of observation group were greater than control group,difference had statistics meaning（P 〈0.05）.The incidence of adverse reaction of two groups had no significant differences （P 〉 0.05）. Conclusions The short-term and long-term curative effect of nedaplatin and 5-Fu combined with intensity modulated conformal radiotherapy in the treatment of middle and advanced cervical cancer are better than radiotherapy,adverse reaction is not higher than control group, it has high security.