肺癌患者T细胞亚群和D-二聚体与临床分期相关性分析

目的研究肺癌患者外周血T淋巴细胞亚群、D-二聚体与临床分期、临床病理分级之间的关系。方法运用流式细胞术和免疫比浊法分别测定80例肺癌患者外周血T淋巴细胞亚群比例和D-二聚体含量。结果临床分期Ⅲ－Ⅳ期（晚期）外周血中cd4＋（%）比例较临床Ⅰ－Ⅱ期（早期）低（P〈0.01）、Ⅲ－Ⅳ期（晚期）CD8＋（%）比例较临床Ⅰ－Ⅱ期（早期）高（P 〈 0.01）、CD4＋/CD8＋（%）比例较临床Ⅰ－Ⅱ期（早期）低（P 〈 0.01），D-二聚体含量（μg/L）较临床Ⅰ－Ⅱ期（早期）高，外周血T细胞亚群比例和D-二聚体的含量与病理类型和病理分级无相关性（P〉 0.05）。结论肺癌患者外周血T淋巴细胞亚群和D-二聚体含量与肺癌的临床分期早晚相关，与肺癌的病理类型和分化级别无关，提示可作为肺癌患者分期的参考指标。

he correlation analysis of T lymphocyte subsets, D -dimer and clinicalstage in lung cancer patients

Objective To discuss the correlationship between subset of T lymphocyte and D-dimer in peripheral blood,and the clinical stage, pathological degree in lung cancer patients. Methods Based on flow cytometry （FCM） and im-munonephelometry the proportion of subset of T lymphocyte and the level of D-dimer were separately analyzed in 80patients of lung cancer. Results The proportion of CD4＋ lymphocyte in the advanced clinical stage （Ⅲ-Ⅳ） was higherthan the early clinical stage （Ⅰ-Ⅱ） , and the proportion of CD8＋ lymphocyte in the advanced clinical stage （Ⅲ-Ⅳ）was lower than the early clinical stage （Ⅰ-Ⅱ） （P 〈 0.01）, the proportion of CD4＋/CD8＋ lymphocyte in the advancedclinical stage （Ⅲ-Ⅳ） was lower than the early clinical stage （ Ⅰ-Ⅱ） （P 〈 0.01）,and the level of D-dimer in the ad-vanced clinical stage （Ⅲ-Ⅳ） was higher than early clinical stage （ Ⅰ-Ⅱ）（ P 〈 0.01）. The proportion ol subset of Tlymphocyte and the content of D-dimer had no relationship with pathological degree, there was no significantly statis-tical differences （P 〉 0.05）. Conclusion The proportion of subset of T lymphocyte and the level of D-dimer in periph-eral blood of lung cancer patients are closely related to the clinical stage of lung cancer which can be used as markersfor clinical stages for lung cancer patients.