| 硒对实验性肝纤维化预防作用研究 |
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| 引用本文： | 赵文海.硒对实验性肝纤维化预防作用研究[J].蚌埠医学院学报,2001,26(1):11-12. |
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| 作者姓名： | 赵文海 |
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| 作者单位： | 江苏省连云港市第一人民医院消化科!222002 |
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| 摘 要： | 目的：探讨抗氧化损伤预防肝纤维化的作用。方法：用四氯化碳制造大鼠肝纤维化模型,造模之日起给予亚硒酸钠,实验结束时测定血清硒、肝细胞膜流动性、肝细胞中羟脯氨酸和丙二醛含量以及组织病理学检查。结果：亚硒酸钠抗氧化损伤可显著保护肝细胞膜的流动性免受损伤,减轻肝细胞的胶原蛋白合成,有效清除氧自由基,组织病理学检查示明显的抗肝纤维化作用。结论：亚硒酸钠抗肝氧化损伤能够预防四氯化碳造成的大鼠肝纤维化。
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| 关 键 词： | 实验性肝硬化 硒 抗氧化剂 预防 |
| 文章编号： | 1000-2200(2001)01-0011-02 |
| 修稿时间： | 2000年6月30日 |
The study on the preventive effect of selenium on experimental hepatic fibrosis |
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| ZHAO Wen-hai.The study on the preventive effect of selenium on experimental hepatic fibrosis[J].Journal of Bengbu Medical College,2001,26(1):11-12. |
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| Authors: | ZHAO Wen-hai |
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| Abstract: | Objective:To investigate the preventive effe ct of antioxidation on experimental hepatic fibrosis in rats. Methods:Rat hepatic fibrosis was induced by hypodermic injection of carbon tetrachloride(CCl_4). The models were given sodium selenite at the same time. The serum selenium,liver hydroxyproline,liver malondiadehyde a nd hepatocyte membrane fluidity were analysed. Histopathological examination was al so done. Results:Antioxidation can protect hepatocyte membrane fluidity again st injury and can alleviate the synthesis of collagen.It can also get rid of fre e radicals validity. Histopathological examination showed that selenium had a pr eventive effect on live fibrosis. Conclusions:Selenium can prevent rat from liver fibrosis induced by CCl_4. |
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| Keywords: | liver cirrhosis experimental selenium antioxidants |
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