超敏C反应蛋白和脑钠肽在急性冠脉综合征中的临床意义

目的探讨急性冠状动脉综合征(ACS)患者血浆脑钠肽(BNP)和超敏C-反应蛋白(hs-CRP)的变化及其临床意义。方法随机选取35例ACS患者,包括不稳定型心绞痛(UAP)15例和急性心肌梗死(AMI)20例,以健康体检者30例为正常对照组,采用荧光免疫法测定血浆BNP水平,乳胶增强免疫透射比浊法检测hs-CRP的浓度。结果ACS组血浆BNP水平和hs-CRP水平与对照组比较显著升高(P<0.01),ACS组血浆BNP和hs-CRP水平呈正相关(r=0.5387,P<0.01)。结论血浆BNP和hs-CRP水平在ACS患者中显著升高,检测血浆BNP和hs-CRP水平对ACS的辅助诊断、疗效观察及预后判断具有重要价值。

Clinical analysis of brain natriuretic peptide and high sensitivity C-reactive protein in patients with acute coronary syndrome

Objective To explore the variation and significance of brain natriuretic peptide(BNP)and high sensitivity C-reactive protein(hs-CRP) in patients with acute coronary syndrome(ACS).Methods 35 patients with ACS were randomly recruited,including 15 patients with unstable angina pectoris(UAP),20 patients with acute myocardial infarction(AMI),and 30 cases of healthy persons were recruited as control group.Plasma concentration of BNP was measured by fluoroimmunoassy and hs-CRP was measured by particle enhanced immuoturbidimetric method.Results The plasma BNP level and hs-CRP level in ACS group increased significantly than those of control group(P<0.01).The levels of BNP were positively correlated with hs-CRP in ACS(r=0.5387,P<0.01).Conclusion Plasma BNP and hs-CRP levels were increased significantly in patients with ACS.Plasma BNP and hs-CRP levels are of great value to the diagnosis,treament and prognosis of ACS.