厚朴提取物、厚朴酚及和厚朴酚的抗炎作用及其机制研究进展

厚朴系木兰科植物厚朴Magnolia officinalis或凹叶厚朴M.officinalis var.biloba的干燥干皮、根皮及枝皮，具有燥湿消痰、下气除满的功效。厚朴提取物、厚朴酚及和厚朴酚是厚朴抗炎的主要活性成分，其抗炎机制有：阻滞磷脂酰肌醇-3激酶/蛋白激酶B（PI3K/Akt）、细胞外调节蛋白激酶/丝裂原活化蛋白激酶（ERK/MAPK）和把关受体-2/丝裂原活化蛋白激酶（TLR/MAPK）信号通路，抑制炎性细胞因子表达；还可通过直接抑制诱导型一氧化氮合酶（iNOS）、环氧化酶-2（COX-2）、5-脂氧化酶（5-LO）的酶活性，阻滞炎症介质一氧化氮、前列腺素（PGs）、白三烯（LTs）的合成和释放，以及抑制组织胺释放等，产生广谱的抗炎作用。厚朴提取物、厚朴酚及和厚朴酚的抗氧化活性也是其抗炎作用的主要机制之一。厚朴为常用的非毒性中药，可以把研究重点放在防治慢性的或退行性疾病的微炎症方面。

Research advances on anti-inflammation and their mechanisms of extract, magnolol and honokiol from Magnoliae Officinalis Cortex

Magnolol Offcinalia Cortex is dry cortex of trunk, root and branch from Magnolia officinalis Rehd. et Wils. or M. officinalis Rehd. et Wils. var. biloba Rehd. et Wils., and have the efficiency of drying dampness to eliminate phlegm, and descending qi to expel fullness. Magnolol and honokiol are principal active compositions against inflammation in Magnoliae Officinalis Cortex. Their mechanisms are: blocking these signaling pathways of PI3K/Akt, ERK/MAPK and TLR/MAPK, to inhibit the expression of inflammatory cytokines; and blocking biosynthesis and release of inflammatory mediators nitric oxide, prostaglandins and leukotrienes by direct inhibition enzymic activity of iNOS, COX-2 and 5-LO; and blocking histamine release; so to produce braodspectrum anti-inflammation. Antioxidation of Mgnoliae Officinalis Cortex, magnolol and honokiol are among the major mechanisms in anti-inflammation too. Magnolol Offcinalia Cortex is a medicinal herb most in use and low toxic, researching focal point should be to prevent and treat for microinflammation in chronic or degenerate diseases.