阿奇霉素对不稳定型心绞痛干预治疗的临床研究

目的　探讨阿奇霉素对不稳定型心绞痛的影响。方法　应用酶联免疫法检测 10 0例不稳定型心绞痛患者血清肺炎衣原体 (CP)特异性抗体IgG。 76例肺炎衣原体抗体IgG阳性者随机分为治疗组 38例和对照组 38例 ,对照组给予扩张冠脉、抗凝等常规治疗 ,治疗组在常规治疗的基础上应用阿奇霉素。结果　治疗组 12～ 18个月内因不稳定型心绞痛再入院、急性心肌梗死和死亡的发生率均明显低于常规治疗的对照组 ,其中 ,不稳定型心绞痛住院的发生率两组比较有显著差异 (P <0 .0 5 )。结论　阿奇霉素可改善CP感染的不稳定型心绞痛的预后 ,减少心血管恶性事件的发生

Clinical study of interventional treatment with azithromycin in unstable angina pectoris

Objective To investigate the influence of azithromycin on unstable angina pectoris(UAP). Methods The specific chlamydia pneumonia(CP) antibody IgG of the 100 UAP cases was measured through enzyme-linked immunosorbent assay(ELISA). 76 CP antibody IgG positive patients were randomly divided into treatment group(n=38) , who were treated with azithromycin on the basis of routine treatment, and control group (n=38), who were given expansion treatment of coronary artery and anticoagulant treatment.Results The readmission rate due to UAP and the incidence of acute myocardial infarction and morbidity were remarkably lower than those of control group, in which the readmission rate due to UAP was significantly different between two groups (P<0.05). Conclusion Azithromycin can improve the prognosis of unstable angina pectoris infected by CP and decrease the occurrence of vicious cardiovascular events.