| 皮肤鳞状细胞癌组织中HPV16 E6/E7的检测 |
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| 引用本文： | 廖文俊,刘彦仿,刘玉峰.皮肤鳞状细胞癌组织中HPV16 E6/E7的检测[J].中国皮肤性病学杂志,2000,14(1):12-13. |
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| 作者姓名： | 廖文俊 刘彦仿 刘玉峰 |
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| 作者单位： | 1. 第四军医大学西京医院皮肤科西安 710032
2. 第四军医大学病理学教研室 |
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| 摘 要： | 目的 了解１６型人乳头瘤病毒Ｅ６／Ｅ７（ＨＰＶ１６Ｅ６／Ｅ７）与皮肤鳞状细胞癌的关系。方法 原位杂交及免疫组织化学染色（ＳＡＢＣ）。结果 ６例患者的癌细胞中检测到ＨＰＶ１６Ｅ６／Ｅ７，阳性信号主要出现在癌细胞的胞浆中。结论 ＨＰＶ１６Ｅ６／Ｅ７可能在皮肤鳞癌的发病中具有重要作用。
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| 关 键 词： | 乳头瘤病毒 鳞状细胞癌 原位杂交 皮肤肿瘤 |
| 修稿时间： | 1998年9月4日 |
Detection of Human Papillomavirus Type 16E6/E7 in Cutaneous Squamous Cell Carcinoma. |
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| Liao Wenjun,Liu Yanfang,Liu Yufeng.Dermatology,Xijing Hospital,The Fourth Military Medical University.Xi'an.Detection of Human Papillomavirus Type 16E6/E7 in Cutaneous Squamous Cell Carcinoma.[J].The Chinese Journal of Dermatovenereology,2000,14(1):12-13. |
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| Authors: | Liao Wenjun Liu Yanfang Liu YufengDermatology Xijing Hospital The Fourth Military Medical UniversityXi'an |
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| Institution: | Liao Wenjun,Liu Yanfang,Liu Yufeng.Dermatology,Xijing Hospital,The Fourth Military Medical University.Xi'an 7100032 |
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| Abstract: | Objective To investigate the relation of human papillomavirus type 16 E 6/E 7 (HPV 16 E 6/E 7) and cutaneous squamous cell carcinoma.Methods With immunohistochemistry (Strepavidin Biotin Complex) and in situ hybridization techniques.Results HPV 16 E 6/E 7 was detected in 6 of 8 cases.the positive signal was observed mainly in cytoplasm of cancer cells.Conclusion HPV 16 E 6/E 7 may play an important role in the carcinogenesis of cutaneous squamous cell carcinoma. |
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| Keywords: | Human papillomavirus Cutaneous squamous cell carcinoma In situ hybridizaion Immunohistochemistry |
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