FK506 facilitates chemical kindling induced by pentylenetetrazole in rats |
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| Authors: | Suzuki K Omura S Ohashi Y Kawai M Iwata Y Tani K Sekine Y Takei N Mori N |
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| Affiliation: | Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, 20-1 Handayama 1-chome, Hamamatsu, Shizuoka 431-3192, Japan. |
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| Abstract: | To clarify the possible role played by calcineurin in kindling development, we examined the effects of pretreatment with FK506, a selective calcineurin inhibitor, on pentylenetetrazole (PTZ) kindling in rats. FK506 facilitated the speed of kindling induced by repeated administration of 30-mg/kg PTZ, while FK506 did not ameliorate acute seizure manifestations after a single injection of PTZ. Our results suggested that calcineurin might exert an inhibitory effect on PTZ kindling. |
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