金橘化学成分的研究(Ⅰ)

目的研究金橘Fortunella margarita(Lour.)Swingle的化学成分。方法金橘成熟果实95%乙醇提取物采用硅胶、ODS、MCI、Sephadex LH-20以及半制备HPLC进行分离纯化,根据理化性质和波谱数据鉴定所得化合物结构。结果从中分离得到17个化合物,分别鉴定为无羁萜(1)、α-香树脂醇(2)、β-谷甾醇(3)、羽扇豆醇(4)、β-香树脂醇(5)、柠檬苦素(6)、表无羁萜醇(7)、滨蒿内酯(8)、东莨菪内酯(9)、citrusinine-Ι(10)、山柰酚(11)、芦丁(12)、(+)-nyasol(13)、金柑苷(14)、acacetin-8-C-neohesperidoside(15)、syringaresinol 4′-O-β-D-glucopyranoside(16)、vanilloloside(17)。结论化合物1~2、4~5、7~10、13、16~17为首次从该植物中分离得到,化合物16为金橘属植物中首次分离得到。

Chemical constituents from Fortunella margarita

AIM To study the chemical constituents from Fortunella margarita(Lour.)Swingle.METHODS The 95% ethanol extract of F.margarita was isolated and purified by silica,ODS,MCI,Sephadex LH-20 and semi-preparative HPLC,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Seventeen compounds were isolated and identified as friedelin(1),α-amyrin(2),β-sitosterol(3),lupeol(4),β-amyrin(5),limonin(6),epifriedelinol(7),scoparone(8),scopoletin(9),citrusinine-Ι(10),kaempferol(11),rutin(12),(+)-nyasol(13),fortunellin(14),acacetin-8-C-neohesperidoside(15),syringaresinol 4′-O-β-D-glucopyranoside(16),vanilloloside(17).CONCLUSION Compounds 1-2,4-5,7-10,13,16-17 are isolated from this plant for the first time,and compound 16 is isolated from genus Rutaceae for the first time.