儿童重症肺炎支原体肺炎中D-二聚体水平的临床意义

目的 分析D-二聚体(D-D)水平对判断儿童肺炎支原体肺炎(MPP)病情严重程度的临床价值及对重症MPP(SMPP)早期识别的意义.方法 选取2018年8月至2020年12月于包头市第四医院儿科住院部收治的MPP患儿255例,其中包含SMPP患儿80例(SMPP组)及非SMPP患儿175例(非SMPP组).观察比较SM...

The clinical significance of D-dimer level in children with severe Mycoplasma pneumoniae pneumonia

Objective Analyze the clinical value of D-dimer(D-D)level in judging the severity of childhood Mycoplasma pneumoniae pneumonia(MPP)and its significance in early identification of severe MPP.Methods Selected 255 children with MPP admitted to the pediatric inpatient department of Baotou Fourth Hospital from August 2018 to December 2020,including 80 children with severe MPP(SMPP group)and 175 children with non-SMPP(non-SMPP group).Observe and compare the D-D,peripheral blood white blood cell(WBC),neutrophil percentage(NEU%),high sensitivity C-reactive protein(hs-CRP),ferritin(SF),changes in the levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST)and lactate dehydrogenase(LDH).Results(1)The levels of NEU%,hs-CRP,SF,ALT,AST,LDH,D-D in SMPP group were higher than those in non-SMPP group(P<0.05);(2)Logistic multivariate regression analysis showed that hs-CRP,LDH,and D-D were independent risk factors for predicting SMPP(P<0.01);(3)The area under the ROC curve of hs-CRP,LDH and D-D combined detection is 0.944,95%CI is 0.909~0.979,sensitivity and specificity are as high as 83.80%and 95.40%,respectively;(4)D-D level also has a good ability to predict SMPP with pleural effusion(P<0.01);(5)The level of D-D in children with SMPP in the recovery phase was significantly lower than that in the acute phase.Conclusion(1)The D-D level of children with SMPP increased significantly;(2)Elevated D-D levels can be used as an early predictor of SMPP and complications;(3)The combined detection of the three indicators of hs-CRP,LDH,and D-D has certain guiding value for judging the occurrence of SMPP in children,and is helpful for early identification of SMPP.