清咽利膈汤治疗小儿传染性单核细胞增多症的临床疗效研究

目的探讨清咽利膈汤治疗小儿传染性单核细胞增多症的疗效与安全性。方法选取2017年1月至2019年6月在深圳市中医院儿科住院治疗的73例中医辨证为“热毒炽盛证”的传染性单核细胞增多症患儿,给予清咽利膈汤口服治疗5 d,采用自身前后对照的研究方法,观察患儿临床症状转归及临床疗效,并对治疗前后白细胞数计数、异型淋巴细胞百分比、EB病毒抗原等结果进行统计学分析。结果采取清咽利膈汤口服治疗总有效率为94.52%(69/73);治疗前后外周血白细胞计数、异型淋巴细胞百分比、天门冬氨酸氨基转移酶、EB病毒抗原、全血EB病毒-DNA均明显下降,差异有统计学意义(P<0.05);治疗后肝、脾、颈部淋巴结逐渐缩小,差异有统计学意义(P<0.05)。结论清咽利膈汤治疗小儿传染性单核细胞增多症疗效显著。

Clinical effect of Qingyan Lige decoction in the treatment of children with infectious mononucleosis

Objective To investigate the efficacy and safety of Qingyan Lige decoction in the treatment of children with infectious mononucleosis.Methods A total of 73 children with infectious mononucleosis(excessive toxic heat syndrome in TCM)were selected,who were hospitalized in the Department of Pediatrics of Shenzhen Hospital of Traditional Chinese Medicine from January 2017 to June 2019,and were given Qingyan Lige decoction orally.On the 5th day of treatment,the self-control study method was used to observe the clinical symptoms and clinical efficacy of the children,and the results of white blood cell(WBC)count,percentage of heterozygous lymphocytes,and EB virus antigen before and after treatment were statistically analyzed.Results The total effective rate of Qingyan Lige decoction was 94.52%(69/73);the peripheral WBC count,the percentage of heterozygous lymphocytes,aspartate aminotransferase,EB virus antigen and whole blood EB virus-DNA were significantly decreased,and the difference was statistically significant(P<0.05).After treatment,the lymph nodes in the liver,spleen and neck were gradually reduced,and the difference was statistically significant(P<0.05).Conclusion The use of Qingyan Lige decoction in the treatment of children with infectious mononucleosis is safe and effective.