Polo样激酶1、真核翻译起始因子5A2在人脑胶质瘤组织的表达及其临床意义

目的:探讨Polo样激酶1(PLK1)和真核翻译起始因子5A2(EIF5A2)在正常脑组织和胶质瘤组织中的表达，分析两者与胶质瘤临床病理特征的关系。方法:采用免疫组织化学方法检测2015年3月至2021年8月大庆市人民医院11例正常脑组织和66例胶质瘤组织中PLK1和EIF5A2的表达水平，结合临床资料行 ...

Expression and clinical significance of Polo-like kinase 1 and eukaryotic translation initiation factor 5A2 in human glioma

Objective To investigate the expression of Polo-like kinase 1(PLK1)and eukaryotic translation initiation factor 5A2(EIF5A2)in normal brain tissues and human brain glioma,and analyze their relationship to clinicopathological features of glioma.Methods In this study,the expression levels of PLK1 and EIF5A2 were detected by immunohistochemistry in 11 cases of normal brain tissues and 66 cases of brain glioma tissues from March 2015 to August 2021 in Daqing People’s Hospital,and correlation analysis was performed by chi-square test combined with clinical data.Results The positive expression rate of PLK1 in brain glioma tissues and normal brain tissues was 71.21%(47/66)and 9.09%(1/11),respectively,and the difference was statistically significant(χ2=15.498,P<0.05).The positive expression rate of EIF5A2 was 74.24%(49/66)in brain glioma tissues and 9.09%(1/11)in normal brain tissue,and the difference was statistically significant(χ2=17.577,P<0.05).The expression levels of PLK1 and EIF5A2 were significantly correlated with histological grade of glioma(respectively,χ2=4.929,5.128,P<0.05).Conclusion PLK1 and EIF5A2 may be related to the occurrence and development of glioma.PLK1 and EIF5A2 can be used as reference indicators to evaluate the biological behavior and prognosis of glioma.