| 石杉碱甲二元醇质体温敏凝胶大鼠鼻腔给药药动学及脑靶向性研究 |
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| 引用本文： | 陈筱瑜,冯连晶,黄庆德,冯玉天娇. 石杉碱甲二元醇质体温敏凝胶大鼠鼻腔给药药动学及脑靶向性研究[J]. 中成药, 2022, 0(2): 350-356 |
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| 作者姓名： | 陈筱瑜 冯连晶 黄庆德 冯玉天娇 |
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| 作者单位： | 福建卫生职业技术学院药学院;福建中医药大学药学院 |
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| 基金项目： | 福建省科技厅引导性项目(2018Y0050)。 |
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| 摘 要： | 目的 研究石杉碱甲二元醇质体温敏凝胶大鼠鼻腔给药药动学及脑靶向性.方法 UPLC-MS/MS法测定大鼠血浆及脑组织中石杉碱甲含量,计算主要药动学参数及脑靶向评价参数.结果 与温敏凝胶鼻腔给药及石杉碱甲注射剂静脉给药比较,二元醇质体温敏凝胶鼻腔给药大鼠脑组织AUC0～t升高(P<0.01),MRT0～t延长(P<0.05...
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| 关 键 词： | 石杉碱甲 二元醇质体 温敏凝胶 鼻腔给药 药动学 脑靶向性 UPLC-MS/MS |
Pharmacokinetics and brain targeting of thermosensitive gel binary ethosomes of huperzine A via nasal administration in rats |
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| Affiliation: | (College of Pharmacy,Fujian Health College,Fuzhou 350101,China;College of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China) |
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| Abstract: | AIM To study the pharmacokinetics and brain targeting of thermosensitive gel binary ethosomes of huperzine A via nasal administration in rats.METHODS UPLC-MS/MS was adopted in the content determination of huperzine A in rat plasma and brain tissue,and main pharmacokinetic parameters and target evaluation parameters were calculated.RESULTS Compared with nasal administration of thermosensitive gel and intravenous administration of huperzine A injection,nasal administration of thermosensitive gel binary ethosomes demonstrated increased AUC0-t(P<0.01) and prolonged MRT0-t(P<0.05) in rat brain tissue,and obvious change in Cmax in rat plasma(P<0.01),whose DTE and DTP were 133.58% and 25.14%,which were 24.45% and 16.77% higher than those of thermosensitive gel,respectively.CONCLUSION The nasal administration of thermosensitive gel binary ethosomes of huperzine A displays brain targeting,which can enhance the distribution of drugs in brain tissue. |
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| Keywords: | huperzine A binary ethosomes thermosensitive gel nasal administration pharmacokinetics brain targeting UPLC-MS/MS |
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