睡眠障碍与帕金森病双向关系的研究进展

帕金森病(PD)是一种好发于老年人的进展性神经退行性疾病，其临床表现主要有运动症状和非运动症状，睡眠障碍是PD常见的非运动症状之一。一系列证据表明，睡眠障碍不仅仅是神经退行性疾病的临床表现，更是导致神经退行性疾病发生和发展的重要危险因素，睡眠障碍和包括PD在内的神经退行性疾病之间存在双向关系，可能的机制有α-突触核蛋白...

Research progress on the bidirectional relationship between sleep disorders and Parkinson's disease

Parkinson's disease(PD)is a progressive neurodegenerative disorder that tends to occur in the elderly.Its clinical manifestations mainly include motor symptoms and non-motor symptoms,with sleep disorders among common non-motor symptoms of PD.The latest lines of evidence show that sleep disorders are not only clinical manifestations of neurodegenerative diseases?but also an important risk factor for the development and progression of neurodegenerative diseases.There is a bidirectional relationship between sleep disorders and neurodegenerative diseases?including PD.The possible mechanisms include accelerated a-synuclein pathology?deposition of Tau protein,inhibition of the glymphatic system,neuroinflammation and changes in the circadian rhythm system.In this article,we review research progress on the bidirectional relationship between sleep disorders and PD,related mechanisms?and the outlook on the treatment of PD through the management of sleep disorders.