输卵管积水对新鲜胚胎移植和冻融胚胎移植妊娠结局的影响

目的 探讨输卵管积水对体外受精新鲜胚胎移植和冻融胚胎移植临床结局的影响.方法 回顾性分析2017年1月至2020年6月因输卵管因素在郑州大学第二附属医院生殖中心行常规体外受精-胚胎移植(in vitro fertilization and embryo transfer,IVF-ET)治疗的496例不育患者的资料,按I...

Effects of hydrosalpinx on the clinical outcome of fresh embryo transfer and frozen-thawed embryo transfer

Objective To evaluate the impact of hydrosalpinx on the clinical outcome of fresh embryo transfer and frozen-thawed embryo transfer(FET).Methods The data of patients of oviduct infertile undergoing IVF-ET were retrospectively analyzed from January 2017 to June 2020 in Reproductive Center of the Second Affiliated Hospital of Zheng Zhou University.Subjects were divided according to different approaches of hydrosalpinx aspiration and tranfer.Patients with obstruction of fallopian tube and fresh embryo transfer(without hydrosalpinx)were taken in Group A as negative control(n=181).Group B were consisted by patients undergoing hydrosalpinx aspiration on fresh embryo transfer day(n=51).Patients in group C had their embryoes frozen and FET after certain treatment of hydrosalpinx problem.It was divided into two subgroups according to ages of freeze, C1 group≤1 year, 136 circles concluded, C2>1 year with 84 circles.Patients in group D had their hydrosalpinx aspiration on FET day(n=44).Pregnancy outcormes were compared.Results The clinical pregnancy rate in group A(69.1%) was significantly higher than that in group B(54.9%)、group C(55.0%) and group D(54.5%)(P<0.05).The embryo implantation rate was the highest in group A(41.9%)compared with other groups(P<0.05).The number of eggs obtained in group A(9.4±6.1) was lower than that in other groups(P<0.05),and the multiple preganancy rate in group A(15.2%) was higher than that in group B(3.9%).There were no significant differences in fertilization rate, number of transferred embryos and ectopic pregnancy rate among groups(P>0.05).A low clinical prenancy rate(53.7%) and embryo implantation rate(31.2%) were found in group C1 were lower than those in group C2(57.1% and 35.7%),but the differences were not statistically significant(P>0.05),the multiple pregnancy rate in group C2 was higher than that in group C1(P<0.05).No other significant differences were found.Conclusion Hydrosalpinx has an adverse effect on the clinical outcome of IVF-ET.Aspiration on the day of fresh embryo transfer or frozen-thawed embryo transfer had no significant difference.Embryo cryopreservation may be considered as an ideal management especially when freezing time is less than a year.