| 播散肿瘤细胞的休眠与存活机制及其在防治实体瘤转移中的作用 |
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| 引用本文： | 阙祖俊,席志超,徐宏喜,田建辉. 播散肿瘤细胞的休眠与存活机制及其在防治实体瘤转移中的作用[J]. 肿瘤防治研究, 2022, 49(2): 154-158. DOI: 10.3971/j.issn.1000-8578.2022.21.0968 |
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| 作者姓名： | 阙祖俊 席志超 徐宏喜 田建辉 |
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| 作者单位： | 1. 200071 上海，上海中医药大学附属市中医医院肿瘤临床医学中心；2. 200032 上海，上海中医药大学附属龙华医院中医肿瘤研究所；3. 201203 上海，上海中医药大学中药学院；4. 201203 上海，中药创新药物研发上海高校工程研究中心 |
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| 基金项目： | 国家自然科学基金(82174017,82174245);上海市青年科技英才扬帆计划(20YF1449900)。 |
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| 摘 要： | 肿瘤转移的防治可显著改善实体瘤患者的生存,然而目前临床上仍缺乏有效的转移防治药物,其根本原因是现有的干预措施和治疗药物都难以实现对转移的精准防治.由于早期术后患者的转移靶器官中早已存在播散肿瘤细胞(DTCs),这些DTCs难以用现有的影像学技术进行检测,也缺乏有效的干预药物和疗效评估体系,而DTCs一旦生长至影像学可检...
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| 关 键 词： | 肿瘤 播散肿瘤细胞 转移 肿瘤休眠 实体瘤 |
| 收稿时间： | 2021-08-27 |
Dormancy and Survival Mechanism of Disseminated Tumor Cell and Its Role in Prevention and Treatment of Solid Tumor Metastasis |
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| QUE Zujun,XI Zhichao,XU Hongxi,TIAN Jianhui. Dormancy and Survival Mechanism of Disseminated Tumor Cell and Its Role in Prevention and Treatment of Solid Tumor Metastasis[J]. Cancer Research on Prevention and Treatment, 2022, 49(2): 154-158. DOI: 10.3971/j.issn.1000-8578.2022.21.0968 |
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| Authors: | QUE Zujun XI Zhichao XU Hongxi TIAN Jianhui |
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| Affiliation: | 1. Clinical Oncology Center, Shanghai Municipal Hospital of TCM, Shanghai University of TCM, Shanghai 200071, China; 2. Institute of Traditional Chinese Medicine Oncology, Longhua Hospital, Shanghai University of TCM, Shanghai 200032, China; 3. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; 4. Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery, Shanghai 201203, China |
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| Abstract: | The prevention and treatment of tumor metastasis can significantly improve the survival of patients with solid tumors.However,there is still a lack of effective drugs for the prevention and treatment of metastasis.The main reason is that the existing intervention and therapeutic drugs are difficult to achieve precise prevention and treatment of metastasis.Due to disseminated tumor cells (DTCs) already exist in the metastatic target organs of early postoperative patients,they are difficult to be detected with existing imaging techniques,and there is a lack of effective intervention drugs and efficacy evaluation systems.When DTCs grow to be detectable by imaging,the patient is already in the advanced stage of cancer,which has become a bottleneck restricting the breakthroughs in metastasis prevention and treatment.This paper reviews the dormancy and survival mechanism of DTCs in metastatic target organs and its intervention strategies,in order to promote the curative effect of metastasis prevention and treatment. |
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| Keywords: | Cancer Disseminated tumor cells Metastasis Tumor dormancy Solid tumor |
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