老年瘙痒症病理机制研究进展

老年瘙痒症发生的病理机制尚未完全阐明。角质细胞间脂质成分改变、膜丝聚蛋白结构不完整、天然保湿因子水平降低、pH值变化及雌激素水平降低等均可导致皮肤屏障功能受损，并在皮肤瘙痒症的发病中起着重要作用。免疫衰老形成的炎性环境、神经的退行性改变与病理性损伤被认为是介导该病发生的自然病因。此外，一些系统性疾病(如慢性肾脏疾病、胆...

Latest research progress on pathological mechanism of senile pruritus

The pathological mechanism of the occurrence of elderly pruritus has not yet been fully elucidated.The changes in lipid composition between keratinocytes,incomplete structure of membrane filaggrin,decreased levels of natural moisturizing factors?changes in pH and decreased levels of estrogen can lead to impaired skin barrier function,and play an important role in the pathogenesis of skin pruritus.An inflammatory environment caused by immune aging,and neurological degenerative changes and pathological damage are also believed to influence the occurrence of senile pruritus.In addition,some systemic diseases are also closely related to the occurrence and development of pruritus in the elderly,such as chronic kidney disease,cholestatic diseases,diabetes,malignant tumors,etc.Further elucidation of the pathological mechanism of pruritus in the elderly can provide useful diagnosis and treatment ideas for the prevention and treatment of diseases.