| 黄曲霉毒素B1诱发昆明鼠高血氨的实验研究 |
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| 引用本文： | 林雅宁,徐忠玉. 黄曲霉毒素B1诱发昆明鼠高血氨的实验研究[J]. 国外医学:临床生物化学与检验学分册, 2014, 0(2): 132-133 |
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| 作者姓名： | 林雅宁 徐忠玉 |
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| 作者单位： | 中国人民解放军第一七五医院／厦门大学附属东南医院检验科,福建漳州363000 |
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| 摘 要： | 目的探讨黄由霉毒素B1对昆明鼠血氨浓度的影响。方法用黄曲霉毒素B1注射昆明鼠10周，每2周测定1次昆明鼠鼠血氨浓度。结果毒素组昆明鼠血氨浓度从40／μmol／L上升到170μmol／L，同时毒素组的血氨浓度相对于对照组呈上升趋势。结论黄曲霉毒素B1可诱发昆明鼠高血氨，推测黄曲霉毒素B1会干扰尿素循环。
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| 关 键 词： | 黄曲霉毒素B1 氨 小鼠 近交系 |
Laboratory study on hyperammonemia of KM mouse induced by aflatoxin BI |
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| Lin Yaning,Xu Zhongyu. Laboratory study on hyperammonemia of KM mouse induced by aflatoxin BI[J]. Foreign Medical Sciences(section of Clinical Biochemistry and Laboratory Medicine, 2014, 0(2): 132-133 |
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| Authors: | Lin Yaning Xu Zhongyu |
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| Affiliation: | (Department of Clinical Laboratory ,the 175th Hospital of PLA /A f filiated Dongnan Hospital of Xiamen University,Zhangzhou,Fujian 363000,China) |
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| Abstract: | Objective To investigate the effect of aflatoxin B1 on blood ammonia in KM mouse. Methods KM mouse were injec- ted with aflatoxin Bl,and the blood ammonia was measured every two week,lasting 10 weeks. Results Aflatoxin B1 induced blood ammonia significantly higher than control group, and the blood ammonia rised from 40μmol/L to 170 μmol/L. Conclusion Hy- perammonemia of KM mouse induced by aflatoxin B1 indicates that aflatoxin B1 can interrupt the urea cycle. |
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| Keywords: | aflatoxin B1 ammonia mice,inbred strains |
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