3种血清心肌标志物联合检测在急性冠状动脉综合征诊断中的应用

目的：探讨肌红蛋白（Mb）、心肌肌钙蛋白I（cTnI）、肌酸激酶同工酶 MB型（CK-MB）联合检测在急性冠状动脉综合征（ACS）诊断中的价值。方法选取85例ACS患者其中不稳定型心绞痛（UA）25例、心肌梗死60例]作为ACS组，除ACS外的冠心病（CHD）患者68例作为CHD组，60例健康体检者作为健康组进行血清 Mb、cTnI、肌酸激酶（CK）、CK-MB检测，并进行统计学分析和评价。结果 ACS组患者血清Mb、cTnI、CK-MB水平均高于CHD组及健康组，差异有统计学意义（P＜0．05）。结论血清 Mb是ACS诊断中敏感且较特异的生化指标，Mb、cTnI、CK-MB联合检测有助于ACS早期的快速诊断和鉴别诊断，具有重要的临床意义。

Clinical significance of myoglobin combined with MB isoenzyme of creatine kinase and cardiac troponin I in the diagnosis of acute coronary syndrome

Objective To investigate the clinical significance of myoglobin（Mb） combined with creatine kinase isoenzyme MB （CK-MB） and cardiac troponin I （cTnI） in the diagnosis of acute coronary syndrome（ACS）. Methods 85 patients with acute coro- nary syndrome and 68 patients with coronary heart disease（CHD） were included in disease group in the study. 60 healthy individu- als were selected as controls. Then Mb,CK-MB and cTnI were detected. All data were analyzed statistically by SPSS 16.0. Results The Mb,CK-MB and cTnI levels in ACS patients were all significantly higher than those in control group（P〉0.05）. Conclusion Myoglobin is a sensitive and specific biochemical indicator for the diagnosis of acute coronary syndrome. Myoglobin combined with CK-MB and cTnI is helpful for the diagnosis of acute coronary syndrome.