宫颈癌组织中p16和p15基因产物表达及其生物学意义

目的 :探索p16、p15基因与宫颈癌发生发展的关系。方法 :应用免疫组化ABC方法对 36例宫颈癌组织中p16、p15基因表达产物进行检测。结果 :p16、p15基因产物的阳性表达率分别为 6 3 9%(2 3/ 36 )、55 6 % (2 0 / 36 ) ,二者的表达率与宫颈癌病理类型无显著关系 (P >0 0 5) ,而与宫颈癌的浸润、转移及病人的生存期显著相关 (P <0 0 5)。结论 :p16、p15基因表达产物可以作为判断宫颈癌预后的指标。

Expression of p16,p15 gene in the Cervix Carcinomas

Objective:In order to investigate the prognostic value of p16,p15 gene in the prediction for patient with cervix carcinoma.Methods:The expression of p16 and p15 gene in 36 cases of cervix carcinoma by immunohisto chemical staining.Results:p16,p15 protein positive rate was 63 9%(23/36),55 6%(20/36),the expression of p16,p15 gene did not correlate with pathological parten ( P >0.05),but with neoplasm invation and with lymph node metastasis and with survival period of patient( P <0 05).Conclusions:p16,p15 gene expression may be a promising predictor for the prognosis of patient with cervix carcinoma.