| 基因多态性与脊柱后纵韧带骨化病发病机制的研究进展 |
| |
| 引用本文： | 赵永飞,吴大江,李明,李明.基因多态性与脊柱后纵韧带骨化病发病机制的研究进展[J].第二军医大学学报,2010,31(6):667-669. |
| |
| 作者姓名： | 赵永飞 吴大江 李明 李明 |
| |
| 作者单位： | 第二军医大学长海医院骨科,上海,200433 |
| |
| 摘 要： | 后纵韧带骨化(ossification of the posterior longitudinal ligament,OPLL)是临床常见脊柱疾患,好发于颈椎,主要表现为神经压迫症状,严重损伤患者健康。其发病机制尚不明确,与遗传因素、基因多态性、机械刺激、代谢异常等多种因素有关,可能是多基因、多因素导致的疾病。该病具有鲜明的遗传特性,与多个基因单核苷酸多态性位点的改变相关。因此,本文就其发病相关基因(COL11A2、BMP-2、TGF-β1、TGF-β3、NPPS、COL6A1、Runx2)的多态性研究进展作一综述,为后续研究奠定基础。
|
| 关 键 词： | 后纵韧带骨化 基因 单核苷酸多态性 |
| 收稿时间： | 2010/1/10 0:00:00 |
| 修稿时间： | 2010/3/19 0:00:00 |
Single nucleotide polymorphisms and ossification of posterior longitudinal ligament: recent progress |
| |
| ZHAO Yong-fei,WU Da-jiang,LI Ming and Li Ming.Single nucleotide polymorphisms and ossification of posterior longitudinal ligament: recent progress[J].Academic Journal of Second Military Medical University,2010,31(6):667-669. |
| |
| Authors: | ZHAO Yong-fei WU Da-jiang LI Ming and Li Ming |
| |
| Institution: | ZHAO Yong-fei,WU Da-jiang,LI Ming Department of Orthopaedics,Changhai Hospital,Second Military Medical University,Shanghai 200433,China |
| |
| Abstract: | Ossification of the posterior longitudinal ligament (OPLL) is common clinical spinal disorders often occurring in the cervical spine,with the main symptom being nerve compression.The specific mechanism of OPLL remains unclear,but genetic factors,single nucleotide polymorphisms (SNPs),mechanical stimulation,metabolism abnormality might be involved in the etiology of the disease.Multiple genetic and environmental factors may contribute to the development of OPLL.OPLL has prominent genetic characteristic,and i... |
| |
| Keywords: | ossification of posterior longitudinal ligament gene single nucleotide polymorphism |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
| 点击此处可从《第二军医大学学报》浏览原始摘要信息 |
| 点击此处可从《第二军医大学学报》下载免费的PDF全文 |
|
