慢性乙肝患者肝脏Fibroscan测量值与实验室检查及影像学检查之间关系的分析

目的 分析瞬时弹性成像(fibroscan)对慢性乙肝患者肝脏硬度测量值与血清纤维化指标、肝功能、血常规、HBV状态及肝脏影像学检查之间的相关性.方法 对68例慢性乙肝患者使用Fibroscan测量肝脏硬度,并同时检测血清纤维化指标(HA、LN、IV-col、PIIIP)血常规、肝功能(ALT、AST、GGT、TBIL及A/G)以及行影像学检查.分析弹性测量值与肝纤指标、转氨酶以及B超或CT结果之间以上指标的相关性.结果 弹性测量值与HA、LN、IV-col、AST、GGT呈正相关(r分别为0.662,0.558,0.562,0.695,0.686).Fibroscan值在HBeAg阳性及阴性组之间无明显差异(P=0.583).在31例影像学正常组患者中,肝脏硬度测量值为7.895±4.007,21例光点增粗中硬度测量值为10.357±4.602,16例肝硬化组为18.342±4.347,正常组与光点增粗组之间比较差异有统计学意义(P=0.038).正常组与肝硬化组比较差异有统计学意义(P=0.00),但光点增粗组与肝硬化组之间差异无统计学意义(P=0.066).结论 Fibroscan测量值与肝功能损伤的程度及血清肝纤维化指标明显相关.

Relationship of Liver Fibroscan Score in Patients with Chronic Hepatitis B,Laboratory Examination and Imaging Examination

Objective To analyze the relationship of the transient elastography (fibroscan) score between serum fibrosis markers,HBV DNA loading,liver function,blood routine examination,as well as imaging examination in patients with chronic hepatitis B. Methods 68 cases of patients with chronic hepatitis B were checked liver stiffness with fibroscan,and taken laboratory examination of serum fibrosis markers,liver function,blood routine examination,as well as imaging. The correlations of these data were analyzed. Resul...