罗哌卡因膈神经阻滞治疗胸外科术后同侧肩膀痛的临床研究

 目的 观察罗哌卡因膈神经阻滞用于治疗胸外科术后同侧肩膀痛的有效性和安全性,探讨其可能的作用机制。方法 择期行后外侧开胸手术患者63例(肺部手术35例,食管手术28例),随机分为治疗组(n=31)和对照组(n=32)。均采用全身麻醉联合硬膜外阻滞,治疗组于关胸前予0.25%罗哌卡因10 mL膈神经阻滞,对照组给予等容量生理盐水。观察不同时点(拔管后即刻、拔管后0.5、1、2、3、4 h)两组患者同侧肩膀痛的发生率和严重程度,同时随访血气,了解有无CO2潴留。结果 60例患者完成本实验(对照组31例,治疗组29例)。对照组有22例发生同侧肩膀痛,占71.0%(22/31);治疗组有5例发生同侧肩膀痛,占17.2%(5/29),两组比较差异有统计学意义(P<0.001)。治疗组患者观察期内视觉模拟评分(visual analogues score,VAS)明显低于对照组(P<0.01)。两组患者术后PaCO2比较差异无统计学意义(P > 0.05)。结论 罗哌卡因膈神经阻滞是治疗胸外科术后同侧肩膀痛安全有效的方法,其阻滞效果与手术方式无关。疼痛发生可能与手术操作、胸腔引流管对胸膜、心包、膈肌的伤害性刺激经膈神经传导,牵涉到同侧肩膀。

Management of ipsilateral shoulder pain after thoracotomy with phrenic nerve infiltration using ropivacaine

Objective To investigate the efficacy and safety of phrenic nerve infiltration in managing ipsilateral shoulder pain after thoracotomy,and also to postulate a reasonable mechanism concerning this kind of pain.Methods Sixty-three patients,undergoing selective lateroposterior thoracotomy(lung surgery:n=35;esophageal surgery:n=28) were randomly divided into two groups:patients in treatment group were given phrenic nerve infiltration with 0.25% ropivacaine just before thoracic closure,while those in control gro...