血小板源性一氧化氮与心血管疾病

一氧化氮是机体内重要的信使和效应分子,在调节血小板功能中起着重要作用。调节血小板的一氧化氮除来源于内皮细胞外,近来发现血小板也可合成一氧化氮。多种心血管疾病如动脉粥样硬化、糖尿病血管并发症及高血压等均伴有血小板活性的改变。心血管疾病中血小板活性改变的原因除内皮受损一氧化氮生成、释放减少外,血小板源性一氧化氮的生成与释放减少也是重要原因。对血小板源性一氧化氮的深入研究有重要的临床意义,并为寻找药物提供了新的靶点和思路。

Platelet-derived nitric oxide and cardiovscular diseases

Nitric oxide is an important signalling and effector molecule which plays an indispensable role in modulating the function of platelets. Recent research revealed that a L-arginine/nitric oxide pathway presented in human platelets and nitric oxide derived from this pathway was called platelet-derived nitric oxide. The impaired synthesis and release of platelet-derived nitric oxide is closely related to the onset and development of some cardiovascular diseases, such as hyper-tension, atherosclerosis and diabetes. Recent progress in the relationship between platelet-derived nitric oxide and some cardiovascular diseases is reviewed in this article. Thorough research in PDNO not only has great clinical significance but also contributes to finding new ideas and new target for drug therapy.