| 磷脂酶A2与高血压大动脉血管重构关系初步研究 |
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| 引用本文： | 曹相玫,景丽,张建中,孙金萍,安欣,郭凤英.磷脂酶A2与高血压大动脉血管重构关系初步研究[J].重庆医学,2010,39(21). |
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| 作者姓名： | 曹相玫 景丽 张建中 孙金萍 安欣 郭凤英 |
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| 作者单位： | 宁夏医科大学,病理系,银川,750004;宁夏医科大学附属医院病理科,银川,750004 |
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| 基金项目： | 国家自然科学基金资助项目，宁夏自然科学基金资助项目 |
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| 摘 要： | 目的探讨磷酸化胞浆型磷脂酶A2(cPLA2)及其上游激酶MEK与高血压大动脉血管平滑肌细胞增殖/凋亡失衡的关系,进一步探讨高血压状态下大动脉血管重构的可能机制。方法将4、16、24周龄组雄性自发性高血压大鼠(SHR)作为实验组,同周龄雄性Wistar大鼠(MKY)作为对照组,各组5只大鼠。采用免疫组化和Western blot对比分析各组动物主动脉平滑肌细胞中cPLA2以及MEK的表达。结果 (1)SHR从8周龄开始血压升高,SHR16、SHR24与同周龄WKY相比差异有统计学意义(P<0.05);(2)各周龄WKY心脏/体质量比值差异无统计学意义(P>0.05),相同周龄SHR心脏/体质量比值较高并随周龄增加心脏/体质量比值呈增高趋势,SHR心脏/体质量比值均高于同周龄对照组;(3)磷酸化cPLA2在SHR4表达率分别为11.71%、46.00%、51.59%,而同周龄WKY表达率分别为29.10%、36.00%、67.84%,随大鼠周龄增加,磷酸化cPLA2表达率逐渐增加(P<0.05);(4)随大鼠周龄增加,磷酸化MEK表达率增加(P<0.05)。结论 MEK的激活与cPLA2活性减弱可能共同参与了高血...
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| 关 键 词： | 高血压 主动脉 血管平滑肌细胞 胞浆型磷脂酶A2 MEK |
Preliminary study on relatiom of phospholipase A_2 and Vascular remolding of hypertensive main artery |
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| CAO Xiang-mei,JING Li,ZHANG Jian-zhong,et al..Preliminary study on relatiom of phospholipase A_2 and Vascular remolding of hypertensive main artery[J].Chongqing Medical Journal,2010,39(21). |
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| Authors: | CAO Xiang-mei JING Li ZHANG Jian-zhong |
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| Institution: | CAO Xiang-mei,JING Li,ZHANG Jian-zhong,et al.(1.Department of Pathology,2.Department of Pathology,Affiliated Hospital,Ningxia Medical University,Yinchuan,Ningxia 750004,China) |
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| Abstract: | Objective To study the relation of phosphorylated cytosolic phospholipase A2(cPLA2)and phosphorated mitogen-cutivated protein kinase kinase(MEK)with proliferation or apoptosis imbalance of vascular smooth muscle cells(VSMC)of large artery and to further study the possible mechanism of vascular remolding of large artery under hypertensive status.Methods The experimental groups included 4-week-old spontaneously hypertensive rats(SHR),16-week-old SHR and 24-week-old SHR,while male Wistar rats(WKY)with the same... |
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| Keywords: | MEK |
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