| 电针内关穴对内毒素休克肾组织诱导型NO合酶表达的影响 |
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| 引用本文： | 邓汝东,李伊为,陈东风,杜少辉,黎辉. 电针内关穴对内毒素休克肾组织诱导型NO合酶表达的影响[J]. 广州中医药大学学报, 2004, 21(1): 31-33 |
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| 作者姓名： | 邓汝东 李伊为 陈东风 杜少辉 黎辉 |
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| 作者单位： | 广州中医药大学解剖教研室,广州,510405;广东省深圳市中医院内科,深圳,518033 |
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| 基金项目： | 国家自然科学基金(编号:39970914)，广东省中医药管理局项目(编号:98447)，深圳市科技局项目(编号:200004087) |
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| 摘 要： | 【目的】探讨电针内关穴对内毒素休克肾组织诱导型一氧化氮合酶(iNOS)表达的作用。[方法]采用脂多糖(LPS)和D氨基半乳糖(D-GalN)致敏的内毒素休克模型,应用免疫组织化学技术检测肾组织iNOS的表达,观察电针内关穴对内毒素休克肾组织iNOS表达的影响。[结果]电针内关穴组的肾组织iNOS的表达低于内毒素模型对照组(P<0.01)。[结论]电针内关穴能部分下调内毒素休克所致肾iNOS的过度表达,这可能是其治疗内毒素休克的机理之一。
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| 关 键 词： | 休克 脓毒性/针灸疗法 肾/针灸效应 一氧化氮合酶/针灸效应 穴 内关 疾病模型 动物 |
| 文章编号： | 1007-3213(2004)01-0031-03 |
| 修稿时间： | 2003-07-24 |
Influence of Electroacupuncture of Point Neiguan (PC6) on iNOS Expression in Kidney of Endotoxin Shock Rats |
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| DENG Rudong,LI Yiwei,CHEN Dongfeng,DU Shaohui,LI Hui Dept. of Anatomy,Guangzhou University of TCM,Guangzhou ,China Dept. of Internal Medicine,Shenzhen Hospital of TCM,Shenzhen ,China. Influence of Electroacupuncture of Point Neiguan (PC6) on iNOS Expression in Kidney of Endotoxin Shock Rats[J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2004, 21(1): 31-33 |
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| Authors: | DENG Rudong LI Yiwei CHEN Dongfeng DU Shaohui LI Hui Dept. of Anatomy Guangzhou University of TCM Guangzhou China Dept. of Internal Medicine Shenzhen Hospital of TCM Shenzhen China |
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| Affiliation: | DENG Rudong,LI Yiwei,CHEN Dongfeng,DU Shaohui,LI Hui Dept. of Anatomy,Guangzhou University of TCM,Guangzhou 510405,China Dept. of Internal Medicine,Shenzhen Hospital of TCM,Shenzhen 518033,China |
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| Abstract: | [Objective] To observe the effect of electro-acupuncture (EA) on point Neiguan (PC6) on inducible nitricoxide synthase (iNOS) expression in kidney df endotoxin shock rats. [Methods] The model of endotoxin shock wasinduced by lipopolysaccharide (LPS) and D-galactosamine. The expression of iNOS in kidney was measured byimmunohistochemistry method. [Results] The expression of iNOS was weaker in EA group than that in model group (P<0.01). [Conclusion] EA on point Neiguan can partially regulate the over-expression of iNOS in kidney withendotoxin shock and this may be one of its therapeutic mechanism. |
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| Keywords: | SHOCK SEPTIC/acup-mox therapy KIDNEY/acup-mox effects NITRIC OXIDE SYNTHASE/acup-mox effects POINT PC6(NEIGUAN) DISEASE MODELS ANIMAL |
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