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A relevant antigenic site in human growth hormone localized in sequence 98–128 |
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| Authors: | C Pea E Poskus AC Paladini |
| Institution: | Departamento de Química Biológica, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, and Centro para el Estudio de las Hormonas Hipofisarias, Buenos Aires, Argentina |
| Abstract: | The immunoreactivity of six synthetic peptides covering different lengths of human growth hormone antigenic region 73–128 has been studied using antisera from rabbits and guinea pigs and sera from two familial prenatal growth hormone-deficient patients submitted to replacement therapy. This survey disclosed that peptide 98–128 was responsible for the total antigenicity of human growth hormone, strongly indicating that a relevant epitope(s) is located in this region of the molecule. |
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