Thienamycin: New Beta-Lactam Antibiotic with Potent Broad-Spectrum Activity |
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| Authors: | Susanne S. Weaver Gerald P. Bodey Barbara M. LeBlanc |
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| Affiliation: | Department of Developmental Therapeutics, The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute, Houston, Texas 77030 |
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| Abstract: | Thienamycin, a new beta-lactam antibiotic, exhibited potent, broad-spectrum activity in vitro against gram-negative bacilli and gram-positive cocci, including many isolates resistant to currently available antibiotics. All isolates were inhibited at concentrations less than or equal to 25 mug/ml, with the exception of 12% of isolates of Enterobacter spp. and 3% of isolates of Serratia marcescens. Its activity decreased with an increase in inoculum concentration of from 10(5) to 10(7) cells per ml. |
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