In vitro selection of resistance to vancomycin in bloodstream isolates ofStaphylococcus haemolyticus andStaphylococcus epidermidis |
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| Authors: | L Herwaldt L Boyken M Pfaller |
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| Institution: | (1) Department of Internal Medicine, University of Iowa College of Medicine, and Department of Veterans Affairs Medical Center, 52242 Iowa City, Iowa, USA;(2) Department of Pathology, University of Iowa College of Medicine, and Department of Veterans Affairs Medical Center, 52242 Iowa City, Iowa, USA;(3) Department of Pathology, Oregon Health Sciences University, 3181 Southwest Sam Jackson Park Road, 97201-3098 Portland, Oregon, USA |
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| Abstract: | The purpose of the study was to determine whether vancomycin-resistant strains ofStaphylococcus haemolyticus could be selected regardless of the initial MIC of vancomycin. Twenty-one bloodstream isolates ofStaphylococcus haemolyticus were studied by broth and agar selection methods. The broth method selected strains for which MICs of vancomycin ranged from 4 to 32 µg/ml and MBCs from 16 to>128 µg/ml. The agar method selected strains for which MICs ranged from 8 to 32 µg/ml and MBCs from 8 to>128 µg/ml. For comparison, seven strains ofStaphylococcus epidermidis were evaluated by the agar selection method. Final MICs of vancomycin ranged from 8 to 16 µg/ml; MBCs ranged from 16 to 64 µg/ml. Clearly, in vitro exposure to vancomycin can select strains ofStaphylococcus haemolyticus andStaphylococcus epidermidis for which MIC values are beyond the susceptible breakpoint. |
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