影响LEEP治疗宫颈上皮内瘤变预后的因素分析

目的:探讨影响宫颈环状电切术(loop electrosurgical excision procedure,LEEP)治疗宫颈上皮内瘤变(cervical intraepithelial neoplasia,CIN)的预后因素。方法:2011年8月至2013年12月选择在我院进行诊治的宫颈上皮内瘤变患者170例,都给予LEEP治疗,观察术后疗效及其不良反应发生情况。结果:所有患者都完成LEEP术,有效率为94.7%;发生不良反应14例,发生率为8.2%,都经过对症处理后好转。Logistic回归模型进行分析结果显示年龄、CIN分级、宫颈糜烂状况是影响宫颈上皮内瘤变预后的主要独立危险因素(P<0.05)。结论:LEEP治疗宫颈上皮内瘤变具有很好的预后疗效,不良反应较少,影响其预后的因素主要为年龄、疾病分级与宫颈糜烂状况。

The prognostic effects analysis of the LEEP treatment of cervical intraepi-thelial neoplasia

Objective:To explore and investigate the prognostic effects of the loop electrosurgical excision procedure ( LEEP ) to treat cervical intraepithelial neoplasia. Methods:Selected 170 cervical intraepithelial neoplasia patients from August 2011 to Decem-ber 2013 in our hospital for treatment,all patients were given LEEP,observed the prognosis efficacy and adverse reactions. Results:All patients were completed LEEP surgery;the effective rate was 94. 7%. 14 cases had adverse reactions,with rate 8. 2% and all improved after symptomatic treatment. Logistic regression model analysis showed that age,disease classification,cervical erosion situation were the major independent risk factors for cervical intraepithelial neoplasia prognosis ( P<0. 05 ) . Conclusion:LEEP treatment for cervical in-traepithelial neoplasia has better prognosis efficacy and fewer side effects,and its main prognostic factors are age,disease classification and cervical erosion conditions.