直肠癌术后患者生存状况的相关因素研究

目的:探讨对直肠癌患者术后生存状况产生影响的相关因素,为评估疾病的预后提供可靠依据。方法:采用回顾性调查统计的方式,选取于2007年2月至2010年5月到我院普外科就诊的直肠癌患者93例,对患者或家属进行问卷调查的形式采集病史,并结合患者住院期间相关检查,统计分析患者生存时间及生存质量评分,采用Log-rank单因素分析及Cox比例风险回归分析,从而确定影响直肠癌患者术后生存状况的相关因素。结果:93例直肠癌患者中,手术后生存时间最长为7年,最短为6个月,中位时间为(1.51±0.24)年,两年生存36例,两年生存率38.71%。患者生存状况与性别、受教育程度、高血压、糖尿病、术前癌胚抗原(carcinoembryonic antigen,CEA)水平没有显著相关性(P>0.05),而与年龄、收入情况、负性情绪事件、肿瘤大小、淋巴结转移、浸润深度、手术方式、化疗与否相关(P<0.05)。结论:直肠癌患者术后生存状况与多方面因素相关,在患者诊断及治疗过程中要综合考虑各因素在疾病进展及预后中起到的作用。

The study on related factors of colorectal cancer patient survival after surgery

Objective:To investigate related factors affecting survival of patients after colorectal cancer surgery and provide a reliable basis for assessing the prognosis of the disease. Methods: 93 cases of colorectal cancer patients were selected in February 2007 to May 2010 in our hospital by retrospective survey . Collected medical history used the questionnaires form of patients or their families combined with the relevant inspection during hospitalization. Analyse survival time and score of life quality. Determine related factors affecting survival of patients after colorectal cancer surgery using Log-rank univariate analysis and Cox proportional hazards re-gression analysis. Results:The maximum of Survival time was seven years a minimum of six months 93 cases of colorectal cancer pa-tients after surgery. the median time was (1. 51 ± 0. 24) years,36 cases of 2-year survival , 38. 71%of 2-year survival rate . Patients living conditions were not significantly correlated with gender, educational level, hypertension, diabetes, preoperative CEA levels ( P>0. 05), but with age, income, negative emotional events, tumor size, lymph node metastasis, depth of invasion, surgical approach and whether chemotherapy or not (P<0. 05) . Conclusion:Patients with colorectal cancer after surgery survival was associated with many factors. We should consider all factors in disease progression and prognosis role in the diagnosis and treatment of patients.